Successful cell division requires the precise and timely coordination of chromosomal,
cytoskeletal and membrane trafficking events. These processes are regulated by the …

Cytokinesis, the final step in cell division, partitions the contents of a single cell into two. In
animal cells, cytokinesis occurs through cortical remodeling orchestrated by the anaphase …

Long ignored as a vestigial remnant of cytokinesis, the mammalian midbody (MB) is
released post-abscission inside large extracellular vesicles called MB remnants (MBRs) …

Large numbers of inhibitors for polo-like kinases and aurora kinases are currently being
evaluated as anticancer drugs. Interest in these drugs is fuelled by the idea that these …

Cytokinesis mediates the physical separation of dividing cells after chromosome
segregation. In animal cell cytokinesis, a contractile ring, mainly composed of actin and …

Cytokinesis is the process by which mitotic cells physically split in two following
chromosome segregation. Dividing animal cells first ingress a cytokinetic furrow and then …

Coordinated progression through the cell cycle is a complex challenge for eukaryotic cells.
Following genotoxic stress, diverse molecular signals must be integrated to establish …

Mitotic spindles are self-organizing protein machines that harness teams of multiple force
generators to drive chromosome segregation. Kinesins are key members of these force …

The active form of the small GTPase RhoA is necessary and sufficient for formation of a
cytokinetic furrow in animal cells. Despite the conceptual simplicity of the process, the …

Proper chromosome segregation into two future daughter cells requires the mitotic spindle to
elongate in anaphase. However, although some candidate proteins are implicated in this …