A comprehensive review of COVID-19 virology, vaccines, variants, and therapeutics

L Forchette, W Sebastian, T Liu - Current medical science, 2021 - Springer
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative pathogen of
the coronavirus disease 2019 (COVID-19), has caused more than 179 million infections and …

Mitigating Covid-19 in the face of emerging virus variants, breakthrough infections and vaccine hesitancy

A Haque, AB Pant - Journal of autoimmunity, 2022 - Elsevier
The emergence and rapid global spread of the new Delta and, more recently, Omicron
variants of SARS-CoV-2 pose a daunting public health emergency. Being an RNA virus, the …

Dynamics of antibody response to BNT162b2 vaccine after six months: a longitudinal prospective study

P Naaber, L Tserel, K Kangro, E Sepp… - The Lancet Regional …, 2021 - thelancet.com
ABSTRACT Background SARS-CoV-2 mRNA vaccines have proven high efficacy, however,
limited data exists on the duration of immune responses and their relation to age and side …

[HTML][HTML] Immunogenicity and safety of a third dose of CoronaVac, and immune persistence of a two-dose schedule, in healthy adults: interim results from two single …

G Zeng, Q Wu, H Pan, M Li, J Yang, L Wang… - The Lancet Infectious …, 2022 - thelancet.com
Background Large-scale vaccination against COVID-19 is being implemented in many
countries with CoronaVac, an inactivated vaccine. We aimed to assess the immune …

Intrinsically determined turnover underlies broad heterogeneity in plasma-cell lifespan

MJ Robinson, Z Ding, MR Dowling, DL Hill… - Immunity, 2023 - cell.com
Antibodies produced by antibody-secreting plasma cells (ASCs) underlie multiple forms of
long-lasting immunity. Here we examined the mechanisms regulating ASC turnover and …

Robust induction of B cell and T cell responses by a third dose of inactivated SARS-CoV-2 vaccine

Y Liu, Q Zeng, C Deng, M Li, L Li, D Liu, M Liu, X Ruan… - Cell discovery, 2022 - nature.com
SARS-CoV-2 inactivated vaccines have shown remarkable efficacy in clinical trials,
especially in reducing severe illness and casualty. However, the waning of humoral …

The role of B cells in COVID-19 infection and vaccination

S Chen, F Guan, F Candotti, K Benlagha… - Frontiers in …, 2022 - frontiersin.org
B cells secrete antibodies and mediate the humoral immune response, making them
extremely important in protective immunity against SARS-CoV-2, which caused the …

COVID‐19 and plasma cells: Is there long‐lived protection?

DC Nguyen, PA Lamothe, MC Woodruff… - Immunological …, 2022 - Wiley Online Library
Summary Infection with SARS‐CoV‐2, the etiology of the ongoing COVID‐19 pandemic, has
resulted in over 450 million cases with more than 6 million deaths worldwide, causing global …

The robustness of cellular immunity determines the fate of SARS-CoV-2 infection

E Moga, E Lynton-Pons, P Domingo - Frontiers in immunology, 2022 - frontiersin.org
Two years after the appearance of the SARS-CoV-2 virus, the causal agent of the current
global pandemic, it is time to analyze the evolution of the immune protection that infection …

Immunogenicity and safety of a third dose, and immune persistence of CoronaVac vaccine in healthy adults aged 18-59 years: interim results from a double-blind …

H Pan, Q Wu, G Zeng, J Yang, D Jiang, X Deng, K Chu… - MedRxiv, 2021 - medrxiv.org
Background Large-scale vaccination is being implemented globally with CoronaVac, an
inactivated vaccine against coronavirus disease 2019 (COVID-19). Immunogenicity and …