Systemic autoimmune diseases are a group of disorders characterized by a failure in self-
tolerance to a wide variety of autoantigens. In genetically predisposed individuals, these …

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) constitutes a group
of rare diseases characterized by necrotizing inflammation of small blood vessels and the …

Systemic autoimmune and inflammatory diseases have a complex and only partially known
pathophysiology with various abnormalities involving all the components of the immune …

The prospects for complement-targeted therapy in ANCA-associated vasculitis have been
enhanced by a recent clinical trial in which C5a receptor 1 (C5aR1) inhibition safely …

Anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) is a rare and
severe autoimmune multisystemic disease. Its pathogenesis involves multiple arms of the …

Autoimmune diseases are characterized by adaptive immune responses against self‐
antigens, including humoral responses resulting in the production of autoantibodies …

Chronic kidney disease (CKD) leads to significant morbidity and mortality worldwide.
Glomerulonephritis (GN) is the second leading cause of CKD resulting in end stage renal …

Neutrophils have traditionally been thought to play only a peripheral role in the genesis of
many autoimmune and inflammatory diseases. However, recent studies in a variety of …

Antineutrophil cytoplasmic autoantibody (ANCA)‐associated vasculitis (AAV) is a rare and
severe systemic autoimmune disease characterized by pauci‐immune necrotizing …

Background Because of their capacity to induce antigen-specific immunosuppression,
tolerogenic dendritic cells are a promising tool for treatment of autoimmune conditions, such …