MicroRNAs (miRNAs) are short non-coding RNAs that inhibit the expression of target genes
by directly binding to their mRNAs. miRNAs are transcribed as precursor molecules, which …

Protein–RNA interactions have crucial roles in various cellular activities, which, when
dysregulated, can lead to a range of human diseases. The identification of small molecules …

Abstract Although 5-methylcytosine (m5C) is a widespread modification in RNAs, its
regulation and biological role in pathological conditions (such as cancer) remain unknown …

Defects in the functions of RNA binding proteins (RBPs) are at the origin of many diseases;
however, targeting RBPs with conventional drugs has proven difficult. PROTACs are a new …

INTRODUCTION Transient receptor potential (TRP) melastatin 2 (TRPM2) is a Ca2+-
permeable, nonselective cation channel implicated in the development of many …

LIN28 is an RNA-binding protein that regulates the maturation of the let-7 family of
microRNAs by bipartite interactions with let-7 precursors through its two distinct cold shock …

The RNA binding protein LIN28 directly modulates the stability and translation of target
mRNAs independently of Let-7; however, the key downstream targets of LIN28 in this …

Highlights•RNA-binding proteins (RBPs) are essential for tumorigenesis, immune evasion,
invasion, migration and metastasis, hence promising drug targets in cancer therapy.•Small …

Simple Summary Proteins are composed of compact domains, often of known three-
dimensional structure, and natively unstructured polypeptide regions. The abundant cold …

LIN28 is a bipartite RNA-binding protein that post-transcriptionally inhibits the biogenesis of
let-7 microRNAs to regulate development and influence disease states. However, the …