Diabetes is one of the fastest growing diseases worldwide, projected to affect 693 million
adults by 2045. Devastating macrovascular complications (cardiovascular disease) and …

The development and progression of diabetic kidney disease (DKD), a highly prevalent
complication of diabetes mellitus, are influenced by both genetic and environmental factors …

During the last decade, there have been substantial advances in the identification and
characterization of DNA sequence variants associated with individual predisposition to type …

Approximately 20% to 40% of patients with type 1 or type 2 diabetes mellitus develop
diabetic kidney disease. This is a clinical syndrome characterized by persistent albuminuria …

Numerous genes for monogenic kidney diseases with classical patterns of inheritance, as
well as genes for complex kidney diseases that manifest in combination with environmental …

Background Although diabetic kidney disease demonstrates both familial clustering and
single nucleotide polymorphism heritability, the specific genetic factors influencing risk …

Diabetic kidney disease (DKD) is one of the most serious complications of both type 1
(T1DM) and type 2 diabetes mellitus (T2DM). Current guidelines recommend a personalized …

Identification of sequence variants robustly associated with predisposition to diabetic kidney
disease (DKD) has the potential to provide insights into the pathophysiological mechanisms …

Metabolic memory, the persistent benefits of early glycaemic control on preventing and/or
delaying the development of diabetic complications, has been observed in the Diabetes …

Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is
associated with severe clinical endpoints. In contrast to cross-sectionally assessed …