Myostatin is a member of the transforming growth factor-beta/bone morphogenetic protein
(TGF-β/BMP) super-family of secreted factors that functions as a potent inhibitor of skeletal …

The discovery of myostatin and our introduction to the “Mighty Mouse” over a decade ago
spurred both basic and applied research and impacted popular culture as well. The …

The aim of this study was to examine the time course induction of select proteolytic [muscle
ring finger-1 (MuRF-1), atrogin-1, forkhead box 3A (FOXO3A), calpain-1, calpain-2] …

Purpose There is mounting evidence that skeletal muscle produces and secretes
biologically active proteins or “myokines” that facilitate metabolic cross talk between organ …

Myostatin is a powerful negative regulator of skeletal muscle mass in mammalian species. It
plays a key role in skeletal muscle homeostasis and has now been well described since its …

A significant proportion of heart failure patients develop skeletal muscle wasting and cardiac
cachexia, which is associated with a very poor prognosis. Recently, myostatin, a cytokine …

Skeletal muscle is a highly specialized tissue that contains two distinct mitochondria
subpopulations, the subsarcolemmal (SS) and the intermyofibrillar (IMF) mitochondria …

Aims In late‐stage chronic heart failure (CHF), elevated cytokines and cachexia are often
observed. Several studies have shown that exercise training exerts beneficial effects on …

The aim of this study was to investigate the effect of leg blood flow restriction (BFR) applied
during a 3-a-side futsal game on strength-related parameters. Twelve male futsal players …

Recent evidence suggests aerobic exercise may help preserve soleus muscle mass during
unloading. The purpose of this investigation was to examine the muscle-specific metabolic …