Histone lysine-specific demethylase 1 (LSD1/KDM1A) was first identified in 2004 as an
epigenetic enzyme able to demethylate specific lysine residues of histone H3, namely …

Innate and acquired resistance towards the conventional therapeutic regimen imposes a
significant challenge for the successful management of cancer for decades. In patients with …

Protein post-translational modifications (PTMs), which are usually enzymatically catalyzed,
are major regulators of protein activity and involved in almost all celluar processes …

Breast cancer (BC) is a kind of malignant cancer in women, and it has become the most
diagnosed cancer worldwide since 2020. Histone methylation is a common biological …

Chemotherapy, targeted therapy, and immunotherapy are effective against most tumors, but
drug resistance remains a barrier to successful treatment. Lysine-specific demethylase 1 …

Simple Summary Regulation of gene expression is important for appropriate cell
development but can also lead to inappropriate cell transformation resulting in cancer …

Biological sex profoundly conditions organismal development and physiology, imposing
wide-ranging effects on cell signaling, metabolism, and immune response. These effects …

The development of resistance to anti-cancer therapeutics remains one of the core issues
preventing the improvement of survival rates in cancer. Therapy resistance can arise in a …

Histone modifications (HMs) contribute to maintaining genomic stability, transcription, DNA
repair, and modulating chromatin in cancer cells. Furthermore, HMs are dynamic and …

Histone demethylases play a critical role in gene transcription regulation and have been
implicated in cancer. Numerous reports have highlighted the overexpression of histone …