Drug–drug interactions between anti-retroviral therapies and drugs of abuse in HIV systems
Introduction: Substance abuse is a common problem among HIV-infected individuals.
Importantly, addictions as well as moderate use of alcohol, smoking, or other illicit drugs …
Importantly, addictions as well as moderate use of alcohol, smoking, or other illicit drugs …
Hepatic, extrahepatic and extracellular vesicle cytochrome p450 2e1 in alcohol and acetaminophen-mediated adverse interactions and potential treatment options
Alcohol and several therapeutic drugs, including acetaminophen, are metabolized by
cytochrome P450 2E1 (CYP2E1) into toxic compounds. At low levels, these compounds are …
cytochrome P450 2E1 (CYP2E1) into toxic compounds. At low levels, these compounds are …
Regulation of cytochrome P450 2e1 expression by ethanol: role of oxidative stress-mediated pkc/jnk/sp1 pathway
CYP2E1 metabolizes ethanol leading to production of reactive oxygen species (ROS) and
acetaldehyde, which are known to cause not only liver damage but also toxicity to other …
acetaldehyde, which are known to cause not only liver damage but also toxicity to other …
Effects of cigarette smoke condensate on oxidative stress, apoptotic cell death, and HIV replication in human monocytic cells
While cigarette smoking is prevalent amongst HIV-infected patients, the effects of cigarette
smoke constituents in cells of myeloid lineage are poorly known. Recently, we have shown …
smoke constituents in cells of myeloid lineage are poorly known. Recently, we have shown …
Specific packaging and circulation of cytochromes P450, especially 2E1 isozyme, in human plasma exosomes and their implications in cellular communications
Cytochrome P450 (CYP) enzymes metabolize the majority of xenobiotics and are mainly
found in hepatic and some extra-hepatic cells. However, their presence and functional role …
found in hepatic and some extra-hepatic cells. However, their presence and functional role …
Effect of mild-to-moderate smoking on viral load, cytokines, oxidative stress, and cytochrome P450 enzymes in HIV-infected individuals
A Ande, C McArthur, L Ayuk, C Awasom, PN Achu… - PloS one, 2015 - journals.plos.org
Mild-to-moderate tobacco smoking is highly prevalent in HIV-infected individuals, and is
known to exacerbate HIV pathogenesis. The objective of this study was to determine the …
known to exacerbate HIV pathogenesis. The objective of this study was to determine the …
Alcohol consumption effect on antiretroviral therapy and HIV-1 pathogenesis: role of cytochrome P450 isozymes
Introduction: Alcohol consumption, which is highly prevalent in HIV-infected individuals,
poses serious concerns in terms of rate of acquisition of HIV-1 infection, HIV-1 replication …
poses serious concerns in terms of rate of acquisition of HIV-1 infection, HIV-1 replication …
Circulating extracellular vesicles containing xenobiotic metabolizing CYP enzymes and their potential roles in extrahepatic cells via cell–cell interactions
K Gerth, S Kodidela, M Mahon, S Haque… - International Journal of …, 2019 - mdpi.com
The cytochrome P450 (CYP) family of enzymes is known to metabolize the majority of
xenobiotics. Hepatocytes, powerhouses of CYP enzymes, are where most drugs are …
xenobiotics. Hepatocytes, powerhouses of CYP enzymes, are where most drugs are …
Effect of polyaryl hydrocarbons on cytotoxicity in monocytic cells: Potential role of cytochromes P450 and oxidative stress pathways
Background Benzo (a) pyrene (BaP), naphthalene (NPh), phenanthrene (Phe), benzo (a)
antharacene (BeA), and benzo (b) fluoranthene (BeF) are known carcinogenic polyaryl …
antharacene (BeA), and benzo (b) fluoranthene (BeF) are known carcinogenic polyaryl …
Differential Effects of Nicotine, Alcohol, and Coexposure on Neuroimmune-Related Protein and Gene Expression in Corticolimbic Brain Regions of Rats
CA Randall, D Sun, PA Randall - ACS Chemical Neuroscience, 2023 - ACS Publications
Nicotine and alcohol co-use is extremely common and their use constitutes two of the most
common causes of preventable death, yet the underlying biological mechanisms are largely …
common causes of preventable death, yet the underlying biological mechanisms are largely …