Diet as a whole, encompassing food composition, calorie intake, and the length and
frequency of fasting periods, affects the time span in which health and functional capacity …

An epidemic of obesity has affected large portions of the world, increasing the risk of
developing many different age-associated diseases, including cancer, cardiovascular …

Caloric restriction (CR) prolongs life span, yet the mechanisms by which it does so remain
poorly understood. Under CR, mice self-impose chronic cycles of 2-hour feeding and 22 …

The geroscience hypothesis proposes that therapy to slow or reverse molecular changes
that occur with aging can delay or prevent multiple chronic diseases and extend healthy …

Chronic caloric restriction (CR) has powerful anticarcinogenic actions in both preclinical and
clinical studies but may be difficult to sustain. As an alternative to CR, there has been …

I. INTRODUCTION 1877 II. STUDYING THE... 1881 III. MICROBIOTA-GUT-BRAIN AXIS...
1907 IV. PATHWAYS OF COMMUNICATION 1911 V. MICROBIOTA AND SYNAPTIC... 1929 …

For several decades, understanding ageing and the processes that limit lifespan have
challenged biologists. Thirty years ago, the biology of ageing gained unprecedented …

Effects of Intermittent Fasting on Health and Aging Evidence is accumulating that eating in a
6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to …

Nutriments have been deemed to impact all physiopathologic processes. Recent evidences
in molecular medicine and clinical trials have demonstrated that adequate nutrition …

Longer human lives have led to a global burden of late-life disease. However, some older
people experience little ill health, a trait that should be extended to the general population …