Role of hemodynamics in initiation/growth of intracranial aneurysms

MR Diagbouga, S Morel, P Bijlenga… - European journal of …, 2018 - Wiley Online Library
Background Intracranial aneurysm (IA) is a disease of the vascular wall resulting in
abnormal enlargement of the vessel lumen. It is a common pathology with a prevalence of …

Disturbed flow's impact on cellular changes indicative of vascular aneurysm initiation, expansion, and rupture: A pathological and methodological review

K Sunderland, J Jiang, F Zhao - Journal of cellular physiology, 2022 - Wiley Online Library
Aneurysms are malformations within the arterial vasculature brought on by the structural
breakdown of the microarchitecture of the vessel wall, with aneurysms posing serious health …

Roles of inflammation in the natural history of intracranial saccular aneurysms

J Wang, L Wei, H Lu, Y Zhu - Journal of the Neurological Sciences, 2021 - Elsevier
Aneurysmal subarachnoid hemorrhage is caused by intracranial aneurysm (IA) rupture and
results in high rates of mortality and morbidity. Factors contributing to IA generation, growth …

Primary cilia control endothelial permeability by regulating expression and location of junction proteins

MR Diagbouga, S Morel, AF Cayron… - Cardiovascular …, 2022 - academic.oup.com
Aims Wall shear stress (WSS) determines intracranial aneurysm (IA) development.
Polycystic kidney disease (PKD) patients have a high IA incidence and risk of rupture …

[HTML][HTML] Effect of aneurysm and patient characteristics on intracranial aneurysm wall thickness

JM Acosta, AF Cayron, N Dupuy, G Pelli… - Frontiers in …, 2021 - frontiersin.org
Background: The circle of Willis is a network of arteries allowing blood supply to the brain.
Bulging of these arteries leads to formation of intracranial aneurysm (IA). Subarachnoid …

Quantitative analysis of unruptured intracranial aneurysm wall thickness and enhancement using 7T high resolution, black blood magnetic resonance imaging

X Liu, J Feng, Z Li, Z Zhang, Q Zhang, Y Jiang… - Journal of …, 2022 - jnis.bmj.com
Background This study was performed to quantify intracranial aneurysm wall thickness
(AWT) and enhancement using 7T MRI, and their relationship with aneurysm size and type …

[HTML][HTML] Shape trumps size: image-based morphological analysis reveals that the 3D shape discriminates intracranial aneurysm disease status better than aneurysm …

N Juchler, S Schilling, P Bijlenga, V Kurtcuoglu… - Frontiers in …, 2022 - frontiersin.org
Background To date, it remains difficult for clinicians to reliably assess the disease status of
intracranial aneurysms. As an aneurysm's 3D shape is strongly dependent on the underlying …

Medial gap: a structural factor at the arterial bifurcation aggravating hemodynamic insult

B Chen, W Tao, S Li, M Zeng, L Zhang… - … of Neuropathology & …, 2022 - academic.oup.com
Previous studies have reported that intracranial aneurysms frequently occur adjacent to the
medial gap. However, the role of the medial gap in aneurysm formation is controversial. We …

[HTML][HTML] Intracranial aneurysm wall (in) stability–current state of knowledge and clinical perspectives

S Morel, P Bijlenga, BR Kwak - Neurosurgical review, 2022 - Springer
Intracranial aneurysm (IA), a local outpouching of cerebral arteries, is present in 3 to 5% of
the population. Once formed, an IA can remain stable, grow, or rupture. Determining the …

In the wall lies the truth: a systematic review of diagnostic markers in intracranial aneurysms

R Jabbarli, L Rauschenbach, TF Dinger… - Brain …, 2020 - Wiley Online Library
Objective: Despite recent advances in molecular biology and genetics, the development of
intracranial aneurysms (IA) is still poorly understood. Elucidation of the processes occurring …