HEMATOPOIESIS IS A life-long process responsible for replenishing both hematopoietic
progenitor cells and mature blood cells from a pool of pluripotent, long-term reconstituting …

THE INTERLEUKIN-6 (IL-6) family of cytokines acts via receptor complexes that contain at
least one subunit of the signal transducing protein gp130. 1 The family comprises IL-6, IL-11 …

Single-cell RNA-seq enables the quantitative characterization of cell types based on global
transcriptome profiles. We present single-cell consensus clustering (SC3), a user-friendly …

Background Cancers result from the accumulation of somatic mutations, and their properties
are thought to reflect the sum of these mutations. However, little is known about the effect of …

Flt3 has emerged as a potential regulator of hematopoietic stem cells (HSC). Sixty percent of
cells in the mouse marrow Lin− Sca1+ c-kit+ HSC pool expressed flt3. Although single cell …

The Notch ligand, Jagged-1, plays an essential role in tissue formation during embryonic
development of primitive organisms. However, little is known regarding the role of Jagged-1 …

Recently, several lines of evidence have indicated an expanded role for thrombopoietin
(TPO) and its receptor, c-mpl, in hematopoiesis. In addition to being the primary …

Human hematopoiesis originates in a population of stem cells with transplantable lympho-
myeloid reconstituting potential, but a method for quantitating such cells has not been …

Ex vivo culture of human hematopoietic cells is a crucial component of many therapeutic
applications. Although current culture conditions have been optimized using quantitative in …

The first lineage commitment step of hematopoietic stem cells (HSC) results in separation
into distinct lymphoid and myeloid differentiation pathways, reflected in the generation of …