Inherited retinal diseases (IRDs) are a clinically complex and heterogenous group of visual
impairment phenotypes caused by pathogenic variants in at least 277 nuclear and …

An efficient mechanism for the sequence‐specific inhibition of gene expression is RNA
interference. In this process, double‐stranded RNA molecules induce cleavage of a selected …

The technology for immobilization of cells and enzymes evolved steadily for the first 25 years
of its existence (1), but in recent years it has reached a plateau, if not a slight decline …

Over the last decade, many catalytically active DNA molecules (deoxyribozymes; DNA
enzymes) have been identified by in vitro selection from random-sequence DNA pools. This …

The metallo DNA duplex containing mercury‐mediated T–T base pairs is an attractive
biomacromolecular nanomaterial which can be applied to nanodevices such as ion sensors …

Allosteric RNAs operate as molecular switches that alter folding and function in response to
ligand binding. A common type of natural allosteric RNAs is the riboswitch; designer RNAs …

Oligonucleotide gene therapy (OGT) agents (eg antisense, deoxyribozymes, siRNA and
CRISPR/Cas) are promising therapeutic tools. Despite extensive efforts, only few OGT drugs …

Photons as fuel: A photoresponsive DNA enzyme was constructed that can work at the
single‐molecule level. Complete ON–OFF photoswitching of RNA digestion was realized by …

Novel molecules are constantly being discovered and developed to find better means of
managing debilitating and fatal diseases, which include cancer in its multiple forms. Among …

Metal‐mediated base pairs have been extensively utilized in many research fields, including
genetic‐code extension, novel therapeutics development, and nanodevice design …