To a large extent, cancer conforms to evolutionary rules defined by the rates at which clones
mutate, adapt and grow. Next-generation sequencing has provided a snapshot of the …

Abstract 293 cell line (widely known as the Human Embryonic Kidney 293 cells) and its
derivatives were the most used cells after HeLa in cell biology studies and after CHO in …

Rapid advances in high-throughput sequencing and a growing realization of the importance
of evolutionary theory to cancer genomics have led to a proliferation of phylogenetic studies …

Cancer is one of the leading causes of death, and despite increased research in recent
years, control of advanced-stage disease and optimal therapeutic responses remain elusive …

Glioblastoma is the most aggressive brain tumor and, even with the current multimodal
therapy, is an invariably lethal cancer with a life expectancy that depends on the tumor …

Micronuclei research has regained its popularity due to the realization that genome chaos, a
rapid and massive genome re-organization under stress, represents a major common …

Many cancers possess an incorrect number of chromosomes, a state described as
aneuploidy. Aneuploidy is often caused by Chromosomal Instability (CIN), a process of …

Cancer research has traditionally focused on the characterization of individual molecular
mechanisms that can contribute to cancer. Due to the multiple levels of genomic and non …

Transient and stable vector transfections have played important roles in illustrating the
function of specific genes/proteins. The general assumption is that such a platform could …

Health is an adaptive state unique to each person. This subjective state must be
distinguished from the objective state of disease. The experience of health and illness (or …