Type 1 and 2 diabetes mellitus: A review on current treatment approach and gene therapy as potential intervention
SY Tan, JLM Wong, YJ Sim, SS Wong… - Diabetes & metabolic …, 2019 - Elsevier
Type 1 and type 2 diabetes mellitus is a serious and lifelong condition commonly
characterised by abnormally elevated blood glucose levels due to a failure in insulin …
characterised by abnormally elevated blood glucose levels due to a failure in insulin …
[HTML][HTML] Human beta cell mass and function in diabetes: Recent advances in knowledge and technologies to understand disease pathogenesis
Background Plasma insulin levels are predominantly the product of the morphological mass
of insulin producing beta cells in the pancreatic islets of Langerhans and the functional …
of insulin producing beta cells in the pancreatic islets of Langerhans and the functional …
Acquisition of dynamic function in human stem cell-derived β cells
Recent advances in human pluripotent stem cell (hPSC) differentiation protocols have
generated insulin-producing cells resembling pancreatic β cells. While these stem cell …
generated insulin-producing cells resembling pancreatic β cells. While these stem cell …
Human hypoimmune primary pancreatic islets avoid rejection and autoimmunity and alleviate diabetes in allogeneic humanized mice
X Hu, C Gattis, AG Olroyd, AM Friera, K White… - Science translational …, 2023 - science.org
Transplantation of allogeneic pancreatic donor islets has successfully been performed in
selected patients with difficult-to-control insulin-dependent diabetes and impaired …
selected patients with difficult-to-control insulin-dependent diabetes and impaired …
Screening out irrelevant cell-based models of disease
The common and persistent failures to translate promising preclinical drug candidates into
clinical success highlight the limited effectiveness of disease models currently used in drug …
clinical success highlight the limited effectiveness of disease models currently used in drug …
Pancreatic islet transplantation in humans: recent progress and future directions
MR Rickels, RP Robertson - Endocrine reviews, 2019 - academic.oup.com
Pancreatic islet transplantation has become an established approach to β-cell replacement
therapy for the treatment of insulin-deficient diabetes. Recent progress in techniques for islet …
therapy for the treatment of insulin-deficient diabetes. Recent progress in techniques for islet …
Engineering islets from stem cells for advanced therapies of diabetes
Diabetes mellitus is a metabolic disorder that affects more than 460 million people
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …
[HTML][HTML] Engineering human stem cell-derived islets to evade immune rejection and promote localized immune tolerance
Immunological protection of transplanted stem cell-derived islet (SC-islet) cells is yet to be
achieved without chronic immunosuppression or encapsulation. Existing genetic …
achieved without chronic immunosuppression or encapsulation. Existing genetic …
[HTML][HTML] Single-cell transcriptome profiling reveals β cell maturation in stem cell-derived islets after transplantation
Human pluripotent stem cells differentiated to insulin-secreting β cells (SC-β cells) in islet
organoids could provide an unlimited cell source for diabetes cell replacement therapy …
organoids could provide an unlimited cell source for diabetes cell replacement therapy …
A nanofibrous encapsulation device for safe delivery of insulin-producing cells to treat type 1 diabetes
Transplantation of stem cell–derived β (SC-β) cells represents a promising therapy for type 1
diabetes (T1D). However, the delivery, maintenance, and retrieval of these cells remain a …
diabetes (T1D). However, the delivery, maintenance, and retrieval of these cells remain a …