The role of myofibroblasts in physiological and pathological tissue repair

R Schuster, F Younesi, M Ezzo… - Cold Spring Harbor …, 2023 - cshperspectives.cshlp.org
Myofibroblasts are the construction workers of wound healing and repair damaged tissues
by producing and organizing collagen/extracellular matrix (ECM) into scar tissue. Scar tissue …

Dermal extracellular matrix molecules in skin development, homeostasis, wound regeneration and diseases

J Huang, S Heng, W Zhang, Y Liu, T Xia, C Ji… - Seminars in Cell & …, 2022 - Elsevier
The extracellular matrix (ECM) is a dynamic structure that surrounds and anchors cellular
components in tissues. In addition to functioning as a structural scaffold for cellular …

Fibroblast and myofibroblast activation in normal tissue repair and fibrosis

FS Younesi, AE Miller, TH Barker, FMV Rossi… - … Reviews Molecular Cell …, 2024 - nature.com
The term 'fibroblast'often serves as a catch-all for a diverse array of mesenchymal cells,
including perivascular cells, stromal progenitor cells and bona fide fibroblasts. Although …

The inflammatory speech of fibroblasts

R Schuster, JS Rockel, M Kapoor… - Immunological …, 2021 - Wiley Online Library
Activation of fibroblasts is a key event during normal tissue repair after injury and the
dysregulated repair processes that result in organ fibrosis. To most researchers, fibroblasts …

Periodontal wound healing and tissue regeneration: a narrative review

YD Cho, KH Kim, YM Lee, Y Ku, YJ Seol - Pharmaceuticals, 2021 - mdpi.com
Periodontal disease is a major public health issue, and various periodontal therapies have
been performed to regenerate periodontal tissues. The periodontium is a complex structure …

Skin wound healing: of players, patterns, and processes

H Sorg, CGG Sorg - European Surgical Research, 2023 - karger.com
Background: Wound healing of the skin is a very complex biological activity. For a better
understanding, an attempt is made to describe and subdivide the different players (cell types …

Platelet CLEC2-podoplanin axis as a promising target for oral cancer treatment

BO Hwang, SY Park, ES Cho, X Zhang, SK Lee… - Frontiers in …, 2021 - frontiersin.org
Cancer tissues are not just simple masses of malignant cells, but rather complex and
heterogeneous collections of cellular and even non-cellular components, such as …

Extracellular vesicle-based biovectors in chronic wound healing: Biogenesis and delivery approaches

D Sharma, A Kumar, E Mostafavi - Molecular Therapy-Nucleic Acids, 2023 - cell.com
Chronic wounds remain an unresolved medical issue because of major social and
therapeutic repercussions that require extensive focus. Recent related theragnostic focuses …

miRNA‐encapsulated abiotic materials and biovectors for cutaneous and oral wound healing: biogenesis, mechanisms, and delivery nanocarriers

A Deka Dey, S Yousefiasl, A Kumar… - Bioengineering & …, 2023 - Wiley Online Library
MicroRNAs (miRNAs) as therapeutic agents have attracted increasing interest in the past
decade owing to their significant effectiveness in treating a wide array of ailments. These …

A scarless healing tale: comparing homeostasis and wound healing of oral mucosa with skin and oesophagus

D Pereira, I Sequeira - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Epithelial tissues are the most rapidly dividing tissues in the body, holding a natural ability
for renewal and regeneration. This ability is crucial for survival as epithelia are essential to …