Post-acute sequelae of COVID (PASC), usually referred to as 'Long COVID'(a phenotype of
COVID-19), is a relatively frequent consequence of SARS-CoV-2 infection, in which …

Recent advances in supramolecular coordination chemistry have allowed chemists to
synthesize macromolecular complexes that exhibit various properties intrinsic to enzymes …

Genetic regulatory proteins inducible by small molecules are useful synthetic biology tools
as sensors and switches. Bacterial allosteric transcription factors (aTFs) are a major class of …

Synthetic biologists engineer complex artificial biological systems to investigate natural
biological phenomena and for a variety of applications. We outline the basic features of …

Protein evolution or engineering studies are traditionally focused on amino acid
substitutions and the way these contribute to fitness. Meanwhile, the insertion and deletion …

Synthetic biology seeks to extend approaches from engineering and computation to
redesign of biology, with goals such as generating new chemicals, improving human health …

Chemical synthesis is a well established route for producing many chemicals on a large
scale, but some drawbacks still exist in this process, such as unstable intermediates …

Allosteric transition, defined as conformational changes induced by ligand binding, is one of
the fundamental properties of proteins. Allostery has been observed and characterized in …

The construction and assembly of artificial allosteric protein switches into information and
energy processing networks connected to both biological and non-biological systems is a …

An understanding of how allostery, the conformational coupling of distant functional sites,
arises in highly evolvable systems is of considerable interest in areas ranging from cell …