On account of the interesting pharmacological properties of hydantoin and 2-thiohydantoin
derivatives, and other purposes such as textile printing, catalysts for polymerizations, their …

A novel scaffold of indoline thiohydantoin was discovered as potent androgen receptor (AR)
antagonist through rational drug designation. Several compounds showed good biological …

Hydrogen bonds (H-bonds) are ubiquitous in peptides and proteins and are central to the
stabilization of their structures. Inter-residue H-bonds between non-adjacent backbone …

Ruthenium (II)-catalyzed C–H functionalization of N-arylhydantoins is herein described. The
biologically relevant hydantoin (imidazolidinedione) heterocycle functions as a weakly …

Targeted protein degradation using small molecules is a novel strategy for drug
development. In order to solve the problem of drug resistance in the treatment of prostate …

Androgen receptor (AR) has been a target of prostate cancer (PC) for nearly six decades.
Recently, downregulating or degrading AR and the mutants especially the splice variant 7 …

Prostate cancer (PC) is a major cause of cancer-related male death in worldwide and the
identification of new and improved potent anti-PC molecules is constantly required. A novel …

Androgen receptor (AR) plays important roles in the development of prostate cancer (PCa),
and therefore it has been regarded as the most important therapeutic target for both …

Androgen receptor (AR) antagonists are widely used for the treatment of prostate cancer
(PCa), but their therapeutic efficacy is usually compromised by the rapid emergence of drug …

A novel bicyclic thiohydantoin fused to pyrrolidine compound, methyl 2-(4-chlorophenyl)-7a-
((4-chlorophenyl) carbamothioyl)-1-oxo-5, 5-diphenyl-3-thioxo-hexahydro-1H-pyrrolo [1, 2-e] …