Phase transitions of associative biomacromolecules
Multivalent proteins and nucleic acids, collectively referred to as multivalent associative
biomacromolecules, provide the driving forces for the formation and compositional …
biomacromolecules, provide the driving forces for the formation and compositional …
A conceptual framework for understanding phase separation and addressing open questions and challenges
Macromolecular phase separation is being recognized for its potential importance and
relevance as a driver of spatial organization within cells. Here, we describe a framework …
relevance as a driver of spatial organization within cells. Here, we describe a framework …
Synthetic protein condensates for cellular and metabolic engineering
Protein condensates are distinct structures assembled in living cells that concentrate
molecules via phase separation in a confined subcellular compartment. In the past decade …
molecules via phase separation in a confined subcellular compartment. In the past decade …
Programmable viscoelasticity in protein-RNA condensates with disordered sticker-spacer polypeptides
Liquid-liquid phase separation of multivalent proteins and RNAs drives the formation of
biomolecular condensates that facilitate membrane-free compartmentalization of subcellular …
biomolecular condensates that facilitate membrane-free compartmentalization of subcellular …
Sequence-dependent material properties of biomolecular condensates and their relation to dilute phase conformations
D Sundaravadivelu Devarajan, J Wang… - Nature …, 2024 - nature.com
Material properties of phase-separated biomolecular condensates, enriched with disordered
proteins, dictate many cellular functions. Contrary to the progress made in understanding the …
proteins, dictate many cellular functions. Contrary to the progress made in understanding the …
Droplet physics and intracellular phase separation
F Jülicher, CA Weber - Annual Review of Condensed Matter …, 2024 - annualreviews.org
Living cells are spatially organized by compartments that can nucleate, grow, and dissolve.
Compartmentalization can emerge by phase separation, leading to the formation of droplets …
Compartmentalization can emerge by phase separation, leading to the formation of droplets …
Sequence-specific interactions determine viscoelasticity and ageing dynamics of protein condensates
Biomolecular condensates are viscoelastic materials. Here we investigate the determinants
of the sequence-encoded and age-dependent viscoelasticity of condensates formed by the …
of the sequence-encoded and age-dependent viscoelasticity of condensates formed by the …
Adenosine triphosphate mediates phase separation of disordered basic proteins by bridging intermolecular interaction networks
Adenosine triphosphate (ATP) is an abundant molecule with crucial cellular roles as the
energy currency and a building block of nucleic acids and for protein phosphorylation. Here …
energy currency and a building block of nucleic acids and for protein phosphorylation. Here …
Fundamental Aspects of Phase-Separated Biomolecular Condensates
Biomolecular condensates, formed through phase separation, are upending our
understanding in much of molecular, cell, and developmental biology. There is an urgent …
understanding in much of molecular, cell, and developmental biology. There is an urgent …
Biomolecular condensates form spatially inhomogeneous network fluids
The functions of biomolecular condensates are thought to be influenced by their material
properties, and these will be determined by the internal organization of molecules within …
properties, and these will be determined by the internal organization of molecules within …