Less data, more knowledge: Building next generation semantic communication networks
Semantic communication is viewed as a revolutionary paradigm that can potentially
transform how we design and operate wireless communication systems. However, despite a …
transform how we design and operate wireless communication systems. However, despite a …
[PDF][PDF] A simple guide to de novo transcriptome assembly and annotation
A transcriptome constructed from short-read RNA sequencing (RNA-seq) is an easily
attainable proxy catalog of protein-coding genes when genome assembly is unnecessary …
attainable proxy catalog of protein-coding genes when genome assembly is unnecessary …
Glioblastoma remodelling of human neural circuits decreases survival
Gliomas synaptically integrate into neural circuits,. Previous research has demonstrated
bidirectional interactions between neurons and glioma cells, with neuronal activity driving …
bidirectional interactions between neurons and glioma cells, with neuronal activity driving …
Vorasidenib and ivosidenib in IDH1-mutant low-grade glioma: a randomized, perioperative phase 1 trial
IK Mellinghoff, M Lu, PY Wen, JW Taylor, EA Maher… - Nature medicine, 2023 - nature.com
Vorasidenib and ivosidenib inhibit mutant forms of isocitrate dehydrogenase (mIDH) and
have shown preliminary clinical activity against m IDH glioma. We evaluated both agents in …
have shown preliminary clinical activity against m IDH glioma. We evaluated both agents in …
A shared disease-associated oligodendrocyte signature among multiple CNS pathologies
Alzheimer's disease (AD) is a complex neurodegenerative disease, perturbing neuronal and
non-neuronal cell populations. In this study, using single-cell transcriptomics, we mapped all …
non-neuronal cell populations. In this study, using single-cell transcriptomics, we mapped all …
[HTML][HTML] Microglial remodeling of the extracellular matrix promotes synapse plasticity
Synapse remodeling is essential to encode experiences into neuronal circuits. Here, we
define a molecular interaction between neurons and microglia that drives experience …
define a molecular interaction between neurons and microglia that drives experience …
Lactate limits CNS autoimmunity by stabilizing HIF-1α in dendritic cells
Dendritic cells (DCs) have a role in the development and activation of self-reactive
pathogenic T cells,. Genetic variants that are associated with the function of DCs have been …
pathogenic T cells,. Genetic variants that are associated with the function of DCs have been …
[HTML][HTML] Vaccine-boosted CAR T crosstalk with host immunity to reject tumors with antigen heterogeneity
Chimeric antigen receptor (CAR) T cell therapy effectively treats human cancer, but the loss
of the antigen recognized by the CAR poses a major obstacle. We found that in vivo vaccine …
of the antigen recognized by the CAR poses a major obstacle. We found that in vivo vaccine …
Gut-licensed IFNγ+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes
Astrocytes are glial cells that are abundant in the central nervous system (CNS) and that
have important homeostatic and disease-promoting functions. However, little is known about …
have important homeostatic and disease-promoting functions. However, little is known about …
Rational design of a JAK1-selective siRNA inhibitor for the modulation of autoimmunity in the skin
Inhibition of Janus kinase (JAK) family enzymes is a popular strategy for treating
inflammatory and autoimmune skin diseases. In the clinic, small molecule JAK inhibitors …
inflammatory and autoimmune skin diseases. In the clinic, small molecule JAK inhibitors …