Less data, more knowledge: Building next generation semantic communication networks

C Chaccour, W Saad, M Debbah… - … Surveys & Tutorials, 2024 - ieeexplore.ieee.org
Semantic communication is viewed as a revolutionary paradigm that can potentially
transform how we design and operate wireless communication systems. However, despite a …

[PDF][PDF] A simple guide to de novo transcriptome assembly and annotation

V Raghavan, L Kraft, F Mesny… - Briefings in …, 2022 - academic.oup.com
A transcriptome constructed from short-read RNA sequencing (RNA-seq) is an easily
attainable proxy catalog of protein-coding genes when genome assembly is unnecessary …

Glioblastoma remodelling of human neural circuits decreases survival

S Krishna, A Choudhury, MB Keough, K Seo, L Ni… - Nature, 2023 - nature.com
Gliomas synaptically integrate into neural circuits,. Previous research has demonstrated
bidirectional interactions between neurons and glioma cells, with neuronal activity driving …

Vorasidenib and ivosidenib in IDH1-mutant low-grade glioma: a randomized, perioperative phase 1 trial

IK Mellinghoff, M Lu, PY Wen, JW Taylor, EA Maher… - Nature medicine, 2023 - nature.com
Vorasidenib and ivosidenib inhibit mutant forms of isocitrate dehydrogenase (mIDH) and
have shown preliminary clinical activity against m IDH glioma. We evaluated both agents in …

A shared disease-associated oligodendrocyte signature among multiple CNS pathologies

M Kenigsbuch, P Bost, S Halevi, Y Chang, S Chen… - Nature …, 2022 - nature.com
Alzheimer's disease (AD) is a complex neurodegenerative disease, perturbing neuronal and
non-neuronal cell populations. In this study, using single-cell transcriptomics, we mapped all …

[HTML][HTML] Microglial remodeling of the extracellular matrix promotes synapse plasticity

PT Nguyen, LC Dorman, S Pan, ID Vainchtein, RT Han… - Cell, 2020 - cell.com
Synapse remodeling is essential to encode experiences into neuronal circuits. Here, we
define a molecular interaction between neurons and microglia that drives experience …

Lactate limits CNS autoimmunity by stabilizing HIF-1α in dendritic cells

LM Sanmarco, JM Rone, CM Polonio… - Nature, 2023 - nature.com
Dendritic cells (DCs) have a role in the development and activation of self-reactive
pathogenic T cells,. Genetic variants that are associated with the function of DCs have been …

[HTML][HTML] Vaccine-boosted CAR T crosstalk with host immunity to reject tumors with antigen heterogeneity

L Ma, A Hostetler, DM Morgan, L Maiorino, I Sulkaj… - Cell, 2023 - cell.com
Chimeric antigen receptor (CAR) T cell therapy effectively treats human cancer, but the loss
of the antigen recognized by the CAR poses a major obstacle. We found that in vivo vaccine …

Gut-licensed IFNγ+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes

LM Sanmarco, MA Wheeler, C Gutiérrez-Vázquez… - Nature, 2021 - nature.com
Astrocytes are glial cells that are abundant in the central nervous system (CNS) and that
have important homeostatic and disease-promoting functions. However, little is known about …

Rational design of a JAK1-selective siRNA inhibitor for the modulation of autoimmunity in the skin

Q Tang, HH Fakih, M Zain UI Abideen… - Nature …, 2023 - nature.com
Inhibition of Janus kinase (JAK) family enzymes is a popular strategy for treating
inflammatory and autoimmune skin diseases. In the clinic, small molecule JAK inhibitors …