Three-dimensional in vitro culture models in oncology research
Cancer is a multifactorial disease that is responsible for 10 million deaths per year. The intra-
and inter-heterogeneity of malignant tumors make it difficult to develop single targeted …
and inter-heterogeneity of malignant tumors make it difficult to develop single targeted …
Bioprinting for the biologist
Building tissues from scratch to explore entirely new cell configurations could revolutionize
fundamental understanding in biology. Bioprinting is an emerging technology to do this …
fundamental understanding in biology. Bioprinting is an emerging technology to do this …
3D cell culture models as recapitulators of the tumor microenvironment for the screening of anti-cancer drugs
Simple Summary Three-dimensional (3D) cell culture models have been proposed as
alternatives for initial drug screening to increase drug development efficiency. In addition to …
alternatives for initial drug screening to increase drug development efficiency. In addition to …
Emergence of FRESH 3D printing as a platform for advanced tissue biofabrication
In tissue engineering, an unresolved challenge is how to build complex 3D scaffolds in order
to recreate the structure and function of human tissues and organs. Additive manufacturing …
to recreate the structure and function of human tissues and organs. Additive manufacturing …
Patient-derived organoids in precision medicine: drug screening, organoid-on-a-chip and living organoid biobank
Z Zhou, L Cong, X Cong - Frontiers in Oncology, 2021 - frontiersin.org
Organoids are in vitro self-assembling, organ-like, three-dimensional cellular structures that
stably retain key characteristics of the respective organs. Organoids can be generated from …
stably retain key characteristics of the respective organs. Organoids can be generated from …
[HTML][HTML] 3D Bioprinted cancer models: Revolutionizing personalized cancer therapy
After cardiovascular disease, cancer is the leading cause of death worldwide with
devastating health and economic consequences, particularly in developing countries. Inter …
devastating health and economic consequences, particularly in developing countries. Inter …
Tumor organoids: synergistic applications, current challenges, and future prospects in cancer therapy
J Qu, FS Kalyani, L Liu, T Cheng… - Cancer …, 2021 - Wiley Online Library
Patient‐derived cancer cells (PDCs) and patient‐derived xenografts (PDXs) are often used
as tumor models, but have many shortcomings. PDCs not only lack diversity in terms of cell …
as tumor models, but have many shortcomings. PDCs not only lack diversity in terms of cell …
In vitro strategies to vascularize 3D physiologically relevant models
A Dellaquila, C Le Bao, D Letourneur… - Advanced …, 2021 - Wiley Online Library
Vascularization of 3D models represents a major challenge of tissue engineering and a key
prerequisite for their clinical and industrial application. The use of prevascularized models …
prerequisite for their clinical and industrial application. The use of prevascularized models …
Current advances in 3D bioprinting for cancer modeling and personalized medicine
N Germain, M Dhayer, S Dekiouk… - International journal of …, 2022 - mdpi.com
Tumor cells evolve in a complex and heterogeneous environment composed of different cell
types and an extracellular matrix. Current 2D culture methods are very limited in their ability …
types and an extracellular matrix. Current 2D culture methods are very limited in their ability …
Mimicking tumor microenvironment by 3D bioprinting: 3D cancer modeling
The tumor microenvironment (TME) typically comprises cancer cells, tumor vasculature,
stromal components like fibroblasts, and host immune cells that assemble to support …
stromal components like fibroblasts, and host immune cells that assemble to support …