A full understanding of Parkinson's Disease etiopathogenesis and of the causes of the
preferential vulnerability of nigrostriatal dopaminergic neurons is still an unsolved puzzle. A …

Midbrain dopaminergic (mDA) neuron development has been an intense area of research
during recent years. This is due in part to a growing interest in regenerative medicine and …

The midbrain dopamine (mDA) system is composed of molecularly and functionally distinct
neuron subtypes that mediate specific behaviours and are linked to various brain diseases …

Background: Aldehydes are highly reactive molecules. While several non-P450 enzyme
systems participate in their metabolism, one of the most important is the aldehyde …

Multiple aldehyde dehydrogenase genes have been identified in many tissues. Aldehyde
dehydrogenase class 1A1 (ALDH1A1) has been identified as highly expressed in …

The generation of individual neuron types in the nervous system is a multistep process
whose endpoint is the expression of neuron type–specific batteries of terminal differentiation …

Abstract The 6‐hydroxydopamine (6‐OHDA) neurotoxic lesion of the midbrain dopamine
(DA) system is one of the most widely used techniques for modelling Parkinson's disease in …

Subpopulations of dopaminergic (DA) neurons within the substantia nigra pars compacta
(SNpc) display a differential vulnerability to loss in Parkinson's disease (PD); however, it is …

In recent years, the meso-diencephalic dopaminergic (mdDA) neurons have been
extensively studied for their association with Parkinson's disease. Thus far, specification of …

Dopamine (DA)-releasing neurons in the substantia nigra pars compacta (SNc DA) inhibit
target cells in the striatum through postsynaptic activation of γ-aminobutyric acid (GABA) …