The discovery of somatic cell nuclear transfer proved that somatic cells can carry the same
genetic code as the zygote, and that activating parts of this code are sufficient to reprogram …

For many years, circular ribonucleic acids (circRNAs) have been counted as aberrant
splicing by-products. Advanced bioinformatics analysis and deep sequencing techniques …

Rationale: Human-induced pluripotent stem cell–derived cardiomyocytes (hiPSC-CM) are
increasingly being used for modeling heart disease and are under development for …

Generation of homogeneous populations of subtype-specific cardiomyocytes (CMs) derived
from human induced pluripotent stem cells (iPSCs) and their comprehensive phenotyping is …

The cardiac action potential (AP) is vital for understanding healthy and diseased cardiac
biology and drug safety testing. However, techniques for high throughput cardiac AP …

Cardiomyocytes derived from induced pluripotent stem cells (iPSC-CMs) represent the best
cell source for cardiac regenerative purposes but retain an immature phenotype after …

Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CM) may
provide an important bridge between animal models and the intact human myocardium …

Alignment, as seen in the native myocardium, is crucial for the fabrication of functional
cardiac tissue. However, it remains unclear whether the control of cardiomyocyte alignment …

Hypertrophic cardiomyopathy (HCM) is an inherited disorder caused primarily by mutations
to thick and thinfilament proteins. Although thin filament mutations are less prevalent than …

In the last few decades, many pathogenic or likely pathogenic genetic mutations in over
hundred different genes have been described for non-ischemic, genetic cardiomyopathies …