Hydrogel biomaterials for application in ocular drug delivery

CR Lynch, PPD Kondiah, YE Choonara… - … in bioengineering and …, 2020 - frontiersin.org
There are many challenges involved in ocular drug delivery. These are a result of the many
tissue barriers and defense mechanisms that are present with the eye; such as the cornea …

Polysaccharides in ocular drug delivery

N Dubashynskaya, D Poshina, S Raik, A Urtti… - Pharmaceutics, 2019 - mdpi.com
Polysaccharides, such as cellulose, hyaluronic acid, alginic acid, and chitosan, as well as
polysaccharide derivatives, have been successfully used to augment drug delivery in the …

Thermoresponsive gels containing gold nanoparticles as smart antibacterial and wound healing agents

MG Arafa, RF El-Kased, MM Elmazar - Scientific reports, 2018 - nature.com
Thermoresponsive gels containing gold nanoparticles (AuNPs) were prepared using
Pluronic® 127 alone (F1) and with hydroxypropyl methylcellulose (F2) at ratios of 15% w/w …

A novel pH-induced thermosensitive hydrogel composed of carboxymethyl chitosan and poloxamer cross-linked by glutaraldehyde for ophthalmic drug delivery

S Yu, X Zhang, G Tan, L Tian, D Liu, Y Liu, X Yang… - Carbohydrate …, 2017 - Elsevier
In this work, a stimuli-responsive three dimensional cross-linked hydrogel system containing
carboxymethyl chitosan (CMC) and poloxamer composed of a poly (ethylene oxide)/poly …

Poloxamer-based in situ gelling thermoresponsive systems for ocular drug delivery applications

KA Soliman, K Ullah, A Shah, DS Jones… - Drug Discovery …, 2019 - Elsevier
Highlights•Poloxamers-based in situ gels are potential vehicles for ocular drug
delivery.•Poloxamers possess reversible thermoresponsive gelling and mucoadhesive …

Antibiotic delivery strategies to treat skin infections when innate antimicrobial defense fails

R Smith, J Russo, J Fiegel, N Brogden - Antibiotics, 2020 - mdpi.com
The epidermal skin barrier protects the body from a host of daily challenges, providing
protection against mechanical insults and the absorption of chemicals and xenobiotics. In …

Formulation strategies to modulate drug release from poloxamer based in situ gelling systems

H Abdeltawab, D Svirskis, M Sharma - Expert Opinion on Drug …, 2020 - Taylor & Francis
Introduction: Poloxamer based in situ gelling systems offer numerous advantages in drug
delivery; however, their application as prolonged-release delivery platforms is limited mainly …

Nanostructured lipid carrier-based pH and temperature dual-responsive hydrogel composed of carboxymethyl chitosan and poloxamer for drug delivery

Y Yu, R Feng, S Yu, J Li, Y Wang, Y Song… - International journal of …, 2018 - Elsevier
The aim of this study was to develop a novel nanostructured lipid carrier (NLC) based dual-
responsive hydrogel for ocular drug delivery of quercetin (QN). NLC loaded with quercetin …

Potential of stimuli-responsive in situ gel system for sustained ocular drug delivery: Recent progress and contemporary research

M Pandey, H Choudhury, A binti Abd Aziz… - Polymers, 2021 - mdpi.com
Eyesight is one of the most well-deserved blessings, amid all the five senses in the human
body. It captures the raw signals from the outside world to create detailed visual images …

Effect of gellan gum on the thermogelation property and drug release profile of Poloxamer 407 based ophthalmic formulation

M Dewan, G Sarkar, M Bhowmik, B Das… - International journal of …, 2017 - Elsevier
The effect of gellan gum on the gelation behavior and in-vitro release of a specific drug
named pilocarpine hydrochloride from different ophthalmic formulations based on …