Natural products targeting macroautophagy signaling in hepatocellular carcinoma therapy: Recent evidence and perspectives

Y Chen, X Tan, W Zhang, Y Li, X Deng… - Phytotherapy …, 2024 - Wiley Online Library
Hepatocellular carcinoma (HCC), presently the second leading cause of global cancer‐
related mortality, continues to pose significant challenges in the realm of medical oncology …

[HTML][HTML] The role of pyroptosis in inflammatory diseases

R Chai, Y Li, L Shui, L Ni, A Zhang - Frontiers in Cell and …, 2023 - frontiersin.org
Programmed cell death has crucial roles in the physiological maturation of an organism, the
maintenance of metabolism, and disease progression. Pyroptosis, a form of programmed …

Ferroptosis, pyroptosis and necroptosis in hepatocellular carcinoma immunotherapy: Mechanisms and immunologic landscape

RJ Liu, XD Yu, SS Yan, ZW Guo… - International …, 2024 - spandidos-publications.com
Hepatocellular carcinoma (HCC), one of the leading causes of cancer‑related mortality
worldwide, is challenging to identify in its early stages and prone to metastasis, and the …

Recent advances in pyroptosis, liver disease, and traditional Chinese medicine: A review

W He, C Xu, D Mao, Y Zheng, N Wang… - Phytotherapy …, 2023 - Wiley Online Library
In recent years, the incidence of liver disease has increased, becoming a major cause of
death. Various liver diseases are intricately linked to pyroptosis, which is one of the most …

[HTML][HTML] Pyroptotic cell death: an emerging therapeutic opportunity for radiotherapy

H Li, T Yang, J Zhang, K Xue, X Ma, B Yu, X Jin - Cell Death Discovery, 2024 - nature.com
Pyroptotic cell death, an inflammatory form of programmed cell death (PCD), is emerging as
a potential therapeutic opportunity for radiotherapy (RT). RT is commonly used for cancer …

Solute carrier family 35 member A2 regulates mitophagy through the PI3K/AKT/mTOR axis, promoting the proliferation, migration, and invasion of osteosarcoma cells

X Luo, J Zhang, C Guo, N Jiang, F Zhang, Q Jiao, K Xu… - Gene, 2024 - Elsevier
The treatment of osteosarcoma patients exhibits individual variability, underscoring the
critical importance of targeted therapy. Although (Solute carrier family 35 member A2) …

[HTML][HTML] Therapeutic Effects of Natural Products on Liver Cancer and Their Potential Mechanisms

J Guo, W Yan, H Duan, D Wang, Y Zhou, D Feng… - Nutrients, 2024 - mdpi.com
Liver cancer ranks third globally among causes of cancer-related deaths, posing a
significant public health challenge. However, current treatments are inadequate, prompting …

Natural autophagy modulators in non-communicable diseases: from autophagy mechanisms to therapeutic potential

T Xu, Y Deng, X Yu, M Li, Y Fu - Acta Pharmacologica Sinica, 2024 - nature.com
Non-communicable diseases (NCDs) are defined as a kind of diseases closely related to
bad behaviors and lifestyles, eg, cardiovascular diseases, cancer, and diabetes. Driven by …

Isogarcinol inhibits nasopharyngeal carcinoma growth through mitochondria-mediated autophagic cell death

J Li, X Shen, C Sun, Y Hou, Y Hu, S Ma, L Huang, L Ma… - Phytomedicine, 2024 - Elsevier
Background and aims Isogarcinol, a natural compound extracted from the fruits of Garcinia
oblongifolia, has potential chemopreventive activity. This study aimed to elucidate the anti …

[HTML][HTML] Halimanes and cancer: ent-halimic acid as a starting material for the synthesis of antitumor drugs

AM Roncero, IE Tobal, RF Moro, D Diez… - Frontiers in …, 2023 - frontiersin.org
The development of new anti-cancer agents is an urgent necessity nowadays, as it is one of
the major causes of mortality worldwide. Many drugs currently used are derived from natural …