Curcumin has been shown to have a wide variety of therapeutic effects, ranging from anti-
inflammatory, chemopreventive, anti-proliferative, and anti-metastatic. This review provides …

Bone is the most common site of metastasis for breast cancer. Bone metastasis significantly
affects both quality of life and survival of the breast cancer patient. Clinically, complications …

While the chemotherapeutic effect of curcumin, one of three major curcuminoids derived
from turmeric, has been reported, largely unexplored are the effects of complex turmeric …

Abstract Treatment of metastatic cancer is one of the biggest challenges in anticancer
therapy. Curcumin is interesting nature polyphenolic compound with unique biological and …

Bone metastases cause significant morbidity and mortality in late-stage breast cancer
patients and are currently considered incurable. Investigators rely on translational models to …

Immune response, proliferation, migration and angiogenesis are juts a few of cellular events
that are regulated by transforming growth factor-β (TGF-β) in cells. A number of studies have …

Bone is a preferred site for breast cancer metastasis and leads to pathologic bone loss due
to increased osteoclast-induced bone resorption. The homing of tumor cells to the bone …

Breast cancer (BCa) bone metastases (BMETs) drive osteolysis via a feed-forward loop
involving tumoral secretion of osteolytic factors (eg, PTHrP) induced by bone-matrix-derived …

Objective: The aim of this study was to investigate the effects of plumbagin (PL), a
naphthoquinone derived from the medicinal plant plumbago zeylanica, on the invasion and …

The biological basis for documented in vivo bone-protective effects of turmeric-derived
curcumin is unclear since curcumin is barely detectable in serum, being rapidly conjugated …