Brown adipose tissue—a translational perspective

AC Carpentier, DP Blondin, F Haman… - Endocrine …, 2023 - academic.oup.com
Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …

Fish consumption and multiple health outcomes: Umbrella review

N Li, X Wu, W Zhuang, L Xia, Y Chen, C Wu… - Trends in Food Science …, 2020 - Elsevier
Background Fish contains a variety of essential nutrients, which may contribute to multiple
health benefits in humans. Conversely, it also may contain contaminants, resulting in …

Dietary fatty acids activate or deactivate brown and beige fat

M Jia, T Xu, YJ Xu, Y Liu - Life Sciences, 2023 - Elsevier
Brown adipose tissue (BAT) and beige fat have been documented to rapidly consume fatty
acids (FAs) rather than deposit of lipid, and they have high capacity to dissipate energy via …

Omega-3 fatty acids and adipose tissue: inflammation and browning

NS Kalupahana, BL Goonapienuwala… - Annual Review of …, 2020 - annualreviews.org
White adipose tissue (WAT) and brown adipose tissue (BAT) are involved in whole-body
energy homeostasis and metabolic regulation. Changes to mass and function of these …

n-3 polyunsaturated fatty acids in the regulation of adipose tissue browning and thermogenesis in obesity: Potential relationship with gut microbiota

J Zapata, A Gallardo, C Romero, R Valenzuela… - … and Essential Fatty …, 2022 - Elsevier
Background: Obesity is a worldwide public health problem characterized by fat tissue
accumulation, favouring adipose tissue and metabolic alterations. Increasing energy …

Targeting energy expenditure—drugs for obesity treatment

CM Jimenez-Munoz, M López, F Albericio… - Pharmaceuticals, 2021 - mdpi.com
Obesity and overweight are associated with lethal diseases. In this context, obese and
overweight individuals infected by COVID-19 are at greater risk of dying. Obesity is treated …

5-HEPE reduces obesity and insulin resistance by promoting adipose tissue browning through GPR119/AMPK/PGC1α activation

Y Zong, M Wang, Y Liu, XY Suo, G Fan, X Yang - Life Sciences, 2023 - Elsevier
Aims Activating thermogenic program in brown adipocytes serves as a potential therapeutic
target for increasing energy expenditure during the treatment of metabolic diseases. 5 (S) …

Differential Anti‐Adipogenic Effects of Eicosapentaenoic and Docosahexaenoic Acids in Obesity

P Zhuang, Y Lu, Q Shou, L Mao, L He… - Molecular nutrition & …, 2019 - Wiley Online Library
Scope To assess the associations of plasma eicosapentaenoic acid (EPA) and
docosahexaenoic acid (DHA) with body fat in a population‐based sample and explore the …

PPARγ-induced upregulation of subcutaneous fat adiponectin secretion, glyceroneogenesis and BCAA oxidation requires mTORC1 activity

ML Andrade, GR Gilio, LA Perandini, AS Peixoto… - … et Biophysica Acta (BBA …, 2021 - Elsevier
The nutrient sensors peroxisome proliferator-activated receptor γ (PPARγ) and mechanistic
target of rapamycin complex 1 (mTORC1) closely interact in the regulation of adipocyte lipid …

Omega-3 supplementation: Impact on Low Chronic Inflammation Associated with Obesity

E López-Millán, JA Gutiérrez-Uribe… - Trends in Food Science …, 2024 - Elsevier
Abstract Background Supplementation of Omega-3 polyunsaturated fatty acids (PUFA),
mainly alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid …