Neurodegenerative diseases are progressive degenerative conditions characterized by the
functional deterioration and ultimate loss of neurons. These incurable and debilitating …

The recently-defined four molecular subgroups of medulloblastoma have required updating
of our understanding of in vitro models to include molecular classification and risk …

Reports from Wuhan suggest that 36% of COVID-19 patients show neurological symptoms,
and cases of viral encephalitis have been reported, suggesting that the virus is neurotropic …

Since the discovery of L-dopa in the middle of the 20th century (1960s), there is not any
neuroprotective therapy available although significant development has been made in the …

Multiple non-animal-based test methods have never been formally validated. In order to use
such new approach methods (NAMs) in a regulatory context, criteria to define their …

There is a paucity of information concerning the developmental neurotoxicity (DNT) hazard
posed by industrial and environmental chemicals. New testing approaches will most likely …

Several neonicotinoids have recently been shown to activate the nicotinic acetylcholine
receptor (nAChR) on human neurons. Moreover, imidacloprid (IMI) and other members of …

The call for a paradigm change in toxicology from the United States National Research
Council in 2007 initiates awareness for the invention and use of human‐relevant alternative …

Neurotoxicity and developmental neurotoxicity are important issues of chemical hazard
assessment. Since the interpretation of animal data and their extrapolation to man is …

Despite effective antiretroviral therapy (ART), HIV-associated neurocognitive disorders
(HAND) are found in nearly one-third of patients. Using a cellular co-culture system …