Transcription–replication conflicts: how they occur and how they are resolved
T García-Muse, A Aguilera - Nature reviews Molecular cell biology, 2016 - nature.com
The frequent occurrence of transcription and DNA replication in cells results in many
encounters, and thus conflicts, between the transcription and replication machineries. These …
encounters, and thus conflicts, between the transcription and replication machineries. These …
Fragile X syndrome
RJ Hagerman, E Berry-Kravis, HC Hazlett… - Nature reviews Disease …, 2017 - nature.com
Fragile X syndrome (FXS) is the leading inherited form of intellectual disability and autism
spectrum disorder, and patients can present with severe behavioural alterations, including …
spectrum disorder, and patients can present with severe behavioural alterations, including …
G4‐associated human diseases
N Maizels - EMBO reports, 2015 - embopress.org
Recent research has established clear connections between G‐quadruplexes and human
disease. Features of quadruplex structures that promote genomic instability have been …
disease. Features of quadruplex structures that promote genomic instability have been …
Replication of G quadruplex DNA
LK Lerner, JE Sale - Genes, 2019 - mdpi.com
A cursory look at any textbook image of DNA replication might suggest that the complex
machine that is the replisome runs smoothly along the chromosomal DNA. However, many …
machine that is the replisome runs smoothly along the chromosomal DNA. However, many …
Promoter-bound trinucleotide repeat mRNA drives epigenetic silencing in fragile X syndrome
Epigenetic gene silencing is seen in several repeat-expansion diseases. In fragile X
syndrome, the most common genetic form of mental retardation, a CGG trinucleotide–repeat …
syndrome, the most common genetic form of mental retardation, a CGG trinucleotide–repeat …
Native functions of short tandem repeats
SE Wright, PK Todd - Elife, 2023 - elifesciences.org
Over a third of the human genome is comprised of repetitive sequences, including more than
a million short tandem repeats (STRs). While studies of the pathologic consequences of …
a million short tandem repeats (STRs). While studies of the pathologic consequences of …
Repeat instability during DNA repair: Insights from model systems
K Usdin, NCM House… - Critical reviews in …, 2015 - Taylor & Francis
The expansion of repeated sequences is the cause of over 30 inherited genetic diseases,
including Huntington disease, myotonic dystrophy (types 1 and 2), fragile X syndrome, many …
including Huntington disease, myotonic dystrophy (types 1 and 2), fragile X syndrome, many …
Insight and Recommendations for Fragile X-Premutation-Associated Conditions from the Fifth International Conference on FMR1 Premutation
The premutation of the fragile X messenger ribonucleoprotein 1 (FMR1) gene is
characterized by an expansion of the CGG trinucleotide repeats (55 to 200 CGGs) in the …
characterized by an expansion of the CGG trinucleotide repeats (55 to 200 CGGs) in the …
The causes of replication stress and their consequences on genome stability and cell fate
I Magdalou, BS Lopez, P Pasero… - Seminars in cell & …, 2014 - Elsevier
Alterations of the dynamics of DNA replication cause genome instability. These alterations
known as “replication stress” have emerged as a major source of genomic instability in pre …
known as “replication stress” have emerged as a major source of genomic instability in pre …
The fragile X mutation impairs homeostatic plasticity in human neurons by blocking synaptic retinoic acid signaling
Z Zhang, SG Marro, Y Zhang, KL Arendt… - Science translational …, 2018 - science.org
Fragile X syndrome (FXS) is an X chromosome–linked disease leading to severe intellectual
disabilities. FXS is caused by inactivation of the fragile X mental retardation 1 (FMR1) gene …
disabilities. FXS is caused by inactivation of the fragile X mental retardation 1 (FMR1) gene …