Naturally occurring CD4+ regulatory T cells (Tregs), which specifically express the
transcription factor FoxP3 in the nucleus and CD25 and CTLA-4 on the cell surface, are a …

The Th2 cytokines interleukin 4 (IL‐4) and IL‐13 and the heterodimeric IL‐4 receptor (IL‐4R)
complexes that they interact with play a key role in the pathogenesis of allergic disorders …

The role of dysbiosis in food allergy (FA) remains unclear. We found that dysbiotic fecal
microbiota in FA infants evolved compositionally over time and failed to protect against FA in …

Food allergies manifest in a variety of clinical conditions within the gastrointestinal tract, skin
and lungs, with the most dramatic and sometimes fatal manifestation being anaphylactic …

Follicular regulatory T (TFR) cells have specialized roles in modulating follicular helper T
(TFH) cell activation of B cells. However, the precise role of TFR cells in controlling antibody …

Allergy is a major public health problem with a high socio‐economic impact. The number of
allergic patients is expected to reach to four billion within two decades when the World's …

The mechanisms by which regulatory T (Treg) cells differentially control allergic and
autoimmune responses remain unclear. We show that Treg cells in food allergy (FA) had …

CD4+ T helper (TH) cells and regulatory T (Treg) cells that respond to common allergens
play an important role in driving and dampening airway inflammation in patients with …

Food allergy affects more than 500 million people in the world, and its prevalence is
increasing at an alarming rate causing serious public health concerns; however, prevention …

T cell heterogeneity is highly relevant to allergic disorders. We resolved the heterogeneity of
human tissue CD3+ T cells during allergic inflammation, focusing on a tissue-specific …