A temporal extracellular transcriptome atlas of human pre-implantation development
Non-invasively evaluating gene expression products in human pre-implantation embryos
remains a significant challenge. Here, we develop a non-invasive method for …
remains a significant challenge. Here, we develop a non-invasive method for …
Chemical genetic identification of PKC epsilon substrates in mouse brain
MP Dugan, LB Ferguson, NT Hertz, RJ Chalkley… - Molecular & Cellular …, 2023 - ASBMB
PKC epsilon (PKCε) plays important roles in behavioral responses to alcohol and in anxiety-
like behavior in rodents, making it a potential drug target for reducing alcohol consumption …
like behavior in rodents, making it a potential drug target for reducing alcohol consumption …
Relating enhancer genetic variation across mammals to complex phenotypes using machine learning
Protein-coding differences between species often fail to explain phenotypic diversity,
suggesting the involvement of genomic elements that regulate gene expression such as …
suggesting the involvement of genomic elements that regulate gene expression such as …
Extracellular matrix in human craniofacial development
DA Cruz Walma, KM Yamada - Journal of Dental Research, 2022 - journals.sagepub.com
The extracellular matrix (ECM) is a highly dynamic amalgamation of structural and signaling
molecules whose quantitative and qualitative modifications drive the distinct programmed …
molecules whose quantitative and qualitative modifications drive the distinct programmed …
Profound effects of dexamethasone on the immunological state, synthesis and secretion capacity of human testicular peritubular cells
YK Stepanov, JD Speidel, C Herrmann, N Schmid… - Cells, 2022 - mdpi.com
The functions of human testicular peritubular cells (HTPCs), forming a small compartment
located between the seminiferous epithelium and the interstitial areas of the testis, are not …
located between the seminiferous epithelium and the interstitial areas of the testis, are not …
CircAGFG1 acts as a sponge of miR-4306 to stimulate esophageal cancer progression by modulating MAPRE2 expression
D Zhang, C Li, N Cheng, L Sun, X Zhou, G Pan, J Zhao - Acta Histochemica, 2021 - Elsevier
Objective This work aims to determine the role of circular RNA (circRNA) AGFG1 and related
molecular mechanism in esophageal squamous cell carcinoma (ESCC) cells. Methods …
molecular mechanism in esophageal squamous cell carcinoma (ESCC) cells. Methods …
Gene expression profiling and protein–protein interaction analysis reveals the dynamic role of MCM7 in Alzheimer's disorder and breast cancer
The interrelation of cancer and Alzheimer's disorder (AD)-associated molecular
mechanisms, reported last decade, paved the path for drug discoveries. In this direction …
mechanisms, reported last decade, paved the path for drug discoveries. In this direction …
Mcrs1 is required for branchial arch and cranial cartilage development
S Keer, H Cousin, K Jourdeuil, KM Neilson… - Developmental …, 2022 - Elsevier
Mcrs1 is a multifunctional protein that is critical for many cellular processes in a wide range
of cell types. Previously, we showed that Mcrs1 binds to the Six1 transcription factor and …
of cell types. Previously, we showed that Mcrs1 binds to the Six1 transcription factor and …
Deep proteome analysis of plasma reveals novel biomarkers of mild cognitive impairment and Alzheimer's disease: A longitudinal study
Ageing is the primary risk factor for AD; however, there is a poor understanding of the
biological mechanisms by which the ageing process contributes to the development of AD in …
biological mechanisms by which the ageing process contributes to the development of AD in …
In silico study for decoding the correlated role of MCM7 gene in progression of breast cancer and Alzheimer's disorder
Breast cancer and Alzheimer's disease (AD) are two of the progressive and detrimental
disorders affecting large population around the globe. While the chemotherapy of breast …
disorders affecting large population around the globe. While the chemotherapy of breast …