A temporal extracellular transcriptome atlas of human pre-implantation development

Q Wu, Z Zhou, Z Yan, M Connel, G Garzo, A Yeo… - Cell Genomics, 2024 - cell.com
Non-invasively evaluating gene expression products in human pre-implantation embryos
remains a significant challenge. Here, we develop a non-invasive method for …

Chemical genetic identification of PKC epsilon substrates in mouse brain

MP Dugan, LB Ferguson, NT Hertz, RJ Chalkley… - Molecular & Cellular …, 2023 - ASBMB
PKC epsilon (PKCε) plays important roles in behavioral responses to alcohol and in anxiety-
like behavior in rodents, making it a potential drug target for reducing alcohol consumption …

Relating enhancer genetic variation across mammals to complex phenotypes using machine learning

IM Kaplow, AJ Lawler, DE Schäffer, C Srinivasan… - Science, 2023 - science.org
Protein-coding differences between species often fail to explain phenotypic diversity,
suggesting the involvement of genomic elements that regulate gene expression such as …

Extracellular matrix in human craniofacial development

DA Cruz Walma, KM Yamada - Journal of Dental Research, 2022 - journals.sagepub.com
The extracellular matrix (ECM) is a highly dynamic amalgamation of structural and signaling
molecules whose quantitative and qualitative modifications drive the distinct programmed …

Profound effects of dexamethasone on the immunological state, synthesis and secretion capacity of human testicular peritubular cells

YK Stepanov, JD Speidel, C Herrmann, N Schmid… - Cells, 2022 - mdpi.com
The functions of human testicular peritubular cells (HTPCs), forming a small compartment
located between the seminiferous epithelium and the interstitial areas of the testis, are not …

CircAGFG1 acts as a sponge of miR-4306 to stimulate esophageal cancer progression by modulating MAPRE2 expression

D Zhang, C Li, N Cheng, L Sun, X Zhou, G Pan, J Zhao - Acta Histochemica, 2021 - Elsevier
Objective This work aims to determine the role of circular RNA (circRNA) AGFG1 and related
molecular mechanism in esophageal squamous cell carcinoma (ESCC) cells. Methods …

Gene expression profiling and protein–protein interaction analysis reveals the dynamic role of MCM7 in Alzheimer's disorder and breast cancer

N Sriram, S Mukherjee, MK Sah - 3 Biotech, 2022 - Springer
The interrelation of cancer and Alzheimer's disorder (AD)-associated molecular
mechanisms, reported last decade, paved the path for drug discoveries. In this direction …

Mcrs1 is required for branchial arch and cranial cartilage development

S Keer, H Cousin, K Jourdeuil, KM Neilson… - Developmental …, 2022 - Elsevier
Mcrs1 is a multifunctional protein that is critical for many cellular processes in a wide range
of cell types. Previously, we showed that Mcrs1 binds to the Six1 transcription factor and …

Deep proteome analysis of plasma reveals novel biomarkers of mild cognitive impairment and Alzheimer's disease: A longitudinal study

G Kaur, A Poljak, P Sachdev - bioRxiv, 2022 - biorxiv.org
Ageing is the primary risk factor for AD; however, there is a poor understanding of the
biological mechanisms by which the ageing process contributes to the development of AD in …

In silico study for decoding the correlated role of MCM7 gene in progression of breast cancer and Alzheimer's disorder

N Sriram, S Mukherjee, MK Sah - bioRxiv, 2021 - biorxiv.org
Breast cancer and Alzheimer's disease (AD) are two of the progressive and detrimental
disorders affecting large population around the globe. While the chemotherapy of breast …