The stability of lipids and other metabolites in human body fluids ranges from very stable
over several days to very unstable within minutes after sample collection. Since the high …

This Feature Article highlights some of the key challenges within the field of metabolomics
and examines what role separation and analytical sciences can play to improve the use of …

Neurodevelopmental disorders are associated with metabolic pathway imbalances;
however, most metabolic measurements are made peripherally, leaving central metabolic …

Background Cerebrospinal fluid (CSF) levels of monoamine metabolites may represent
biomarkers of Parkinson's disease (PD). Objective The aim of this study was quantification of …

Introduction Interest in cell culture metabolomics has increased greatly in recent years
because of its many potential applications and advantages (eg, in toxicology). The first …

Objective Impaired amine metabolism has been associated with the etiology of migraine,
that is, why patients continue to get migraine attacks. However, evidence from cerebrospinal …

Neurodevelopmental disorders are associated with metabolic pathway imbalances;
however, most metabolic measurements are made peripherally, leaving central metabolic …

Methods Plasma samples from 8 Dutch cohorts (n= 10,153: 2,800 migraine patients and
7,353 controls) were profiled on a 1H-NMR-based metabolomics platform, to quantify 146 …

Erros na fase pré-analítica podem explicar os resultados que levam a testes
clinicolaboratoriais desnecessários, induzindo decisões clínicas inadequadas, trazendo …

One major key for successful application of metabolomics in biomedical research are
sensitive, reproducible, and robust analytical methods. However, even the best analytical …