Many advances in our understanding of the molecules that regulate the development,
differentiation and function of T cells have been made over the past few years. One …

The development of mature blood cells of distinct lineages, from the hematopoietic stem
cells (HSCs), involves a progressive restriction of differentiation potential and the …

Recent advances in technology have led to a dramatic increase in the number of available
transcription factor ChIP-seq and ChIP-chip data sets. Understanding the motif content of …

Blood cell development relies on the expansion and maintenance of haematopoietic stem
and progenitor cells in the embryo. By gene targeting in mouse embryonic stem cells, we …

Cellular decision-making is mediated by a complex interplay of external stimuli with the
intracellular environment, in particular transcription factor regulatory networks. Here we have …

The zinc-finger transcription factor GATA-2 plays a critical role in maintaining the pool of
early hematopoietic cells. To define its specific functions in the proliferation, survival, and …

Despite the importance of blood platelets in health and disease, the mechanisms regulating
their formation within megakaryocytes are unknown. We generated mice lacking the …

The T cell leukemia oncoprotein SCL/tal-1, a basic–helix-loop-helix transcription factor, is
required for production of embryonic red blood cells in the mouse yolk sac. To define roles in …

The LIM domain protein rbtn2 is associated with T cell acute leukemias. We demonstrate
that rbtn2 is a nuclear protein expressed in the erythroid lineage in vivo, and using …

The scl gene encodes a basic-helix-loop-helix transcription factor which was identified
through its involvement in chromosomal translocations in T-cell leukemia. To elucidate its …