Dipolar aprotic and ethereal solvents comprise just over 40% of all organic solvents utilized
in synthetic organic, medicinal, and process chemistry. Unfortunately, many of the common …

The synthesis of amides remains one of the most important transformations and it is one of
the more frequently performed reactions. In the pharmaceutical industry, the formation of the …

Currently, smallpox, caused by the variola virus belonging to the poxvirus family, has been
completely eradicated according to the WHO. However, other representatives of poxviruses …

A metal-free method for the vicinal thiosulfonylation of unactivated alkenes with
thiosulfonates using 9-mesityl-10-methylacridinium perchlorate as the photo-organocatalyst …

The Schmidt reaction has been an efficient and widely used synthetic approach to amides
and nitriles since its discovery in 1923. However, its application often entails the use of …

Formation of amide bonds is of immanent importance in organic and synthetic medicinal
chemistry. Its presence in “traditional” small‐molecule active pharmaceutical ingredients, in …

Amide bond is not only the building block of proteins, peptides, and some synthetic polymers
but is also commonly found in drugs, materials, and insecticides. Moreover, amides are vital …

A methodology is reported for preparing amides using amines as an acyl source. The
protocol involves the visible-light-promoted oxidative amidation of amines with pyrazole to …

Despite the fact that the variola virus is considered eradicated, the search for new small
molecules with activity against orthopoxviruses remains an important task, especially in the …

Through modification of the skeleton of Sitagliptin and Vildagliptin, we successfully
synthesized and built-up four series of 1, 2, 4-triazole derivatives, containing N, O …