Microglia-astrocyte crosstalk has recently been at the forefront of glial research. Emerging
evidence illustrates that microglia-and astrocyte-derived signals are the functional …

Neither normal brain function nor the pathological processes involved in neurological
diseases can be adequately understood without knowledge of the release, uptake and …

The brain possesses two intricate mechanisms that fulfill its continuous metabolic needs:
cerebral autoregulation, which ensures constant cerebral blood flow over a wide range of …

This review discusses the evidence supporting a role for ATP signaling (operated by P 2 X
and P 2 Y receptors) and adenosine signaling (mainly operated by A 1 and A 2A receptors) …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by
progressive loss of motor neurons in the CNS. Astrocytes play a critical role in disease …

Over the past several decades a large amount of data have established that glial cells, the
main cell population in the brain, dynamically interact with neurons and thus impact their …

Inflammation may be caused by a variety of factors and is a hallmark of a plethora of acute
and chronic diseases. The purpose of inflammation is to eliminate the initial cell injury …

Background Glia-mediated neuroinflammation is related to brain injury exacerbation after
cerebral ischemia/reperfusion (I/R) injury. Astrocytic hemichannels or gap junctions, which …

Astrocytes interact dynamically with neurons by modifying synaptic activity and plasticity.
This interplay occurs through a process named gliotransmission, meaning that neuroactive …

In Alzheimer's disease (AD), astrocyte properties are modified but their involvement in this
pathology is only beginning to be appreciated. The expression of connexins, proteins …