Abstract Isoindolin-1-one or 1-isoindolinone framework is referred to phthalimidines or
benzo fused γ-lactams of the corresponding γ-amino carboxylic acids and has been of prime …

Phthalimide derivatives have been presenting several promising biological activities in the
literature, such as anti-inflammatory, analgesic, antitumor, antimicrobial and anticonvulsant …

A group of 30 cyclic imides (1–10a-c) was designed for evaluation as a selective COX-2
inhibitor and investigated in vivo for anti-inflammatory and analgesic activities. Compounds …

New series of phthalimide-sulfonylurea hybrids were prepared and examined for their in
vivo anti-hyperglycemic activities in STZ-induced hyperglycemic rats using glibenclamide as …

Trimellitimides 6–21 were prepared and investigated in vivo for anti-inflammatory and
ulcerogenic effects and in vitro for cytotoxicity. They were subjected to in vitro …

New quinazoline-sulfonylurea hybrids were prepared and examined for their in vivo anti-
hyperglycemic activities in STZ-induced hyperglycemic rats using glibenclamide as a …

A synthesized and promising biologically hypoglycemic compound 5, 6-Dichloro-2-[2-
(pyridin-2-yl) ethyl] isoindoline-1, 3-dione (5e) was studied for its binding to a model protein …

It is estimated that the worldwide prevalence of leishmaniasis is around 12 million
individuals in 80 countries, with 400,000 new cases per year. In the search for new …

The synthesis, characterization and biological evaluation of a library of isoindoline-1, 3-
dione-based oximes and benzenesulfonamide hydrazones is disclosed. The set of …

Chagas disease is a parasitic infection caused by protozoan Trypanosoma cruzi that affects
approximately 6–7 million people worldwide. Benznidazole is the only drug approved for …