Chronic lymphocytic leukaemia (CLL) is the most common leukaemia among the adults in
the Western World. CLL (and the corresponding nodal entity small lymphocytic lymphoma …

Introduction: Lenalidomide is an immunomodulatory drug (IMiD) with a unique mode of
action (MOA) that may vary across disease-type. It is currently approved in multiple myeloma …

Altered metabolism is a hallmark of both cell division and cancer. Chronic lymphocytic
leukemia (CLL) cells circulate between peripheral blood (PB) and lymph nodes (LNs) …

How to develop highly informative serology assays to evaluate the quality of immune
protection against coronavirus disease‐19 (COVID‐19) has been a global pursuit over the …

Abstract Background The CXCR4-CXCL12 axis plays an important role in the chronic
lymphocytic leukemia (CLL)-microenvironment interaction. Overexpression of CXCR4 has …

BACKGROUND Chronic lymphocytic leukemia (CLL) is the most prevalent adult leukemia,
with profound disease‐related cellular, humoral, and innate immune suppression. The …

Over the last decade, the active role of the microenvironment in the pathogenesis,
development and drug resistance of B cell malignancies has been clearly established. It is …

The discovery of non-coding RNAs (ncRNAs) and their role in tumor onset and progression
has revolutionized the way scientists and clinicians study cancers. This discovery opened …

Evading apoptosis and sustained survival signaling pathways are two central hallmarks of B-
cell chronic lymphocytic leukemia (B-CLL) cells. In this regard, nurse-like cells (NLC), the …

Macrophages are terminally differentiated innate immune cells. Through their activation,
they can be polarized towards the pro-inflammatory M1 type or the wound healing …