Background: Canada and the United States have the highest levels of prescription opioid
consumption in the world. In an attempt to curb the opioid epidemic, a variety of interventions …

Aims Prescribing is a complex task and a high risk area of clinical practice. Poor prescribing
occurs across staff grades and settings but new prescribers are attributed much of the …

Background Published data from 1998 revealed that most patients treated for migraine in an
emergency department received opioids. Over the intervening years, a large body of …

Neuraxial anesthesia is preferable for cesarean deliveries (CDs), as it allows mothers to be
awake and avoids the associated risks of general anesthesia. However, an estimated 53 …

Pain in patients with impaired renal function may be a significant problem requiring
treatment with opioids. However, pharmacokinetic and metabolic changes associated with …

Metabolic reactions that occur at alkylamino moieties may provide insight into the roles of
these moieties when they are parts of drug molecules that act at different receptors. N …

Objectives. To investigate the prevalence of chronic pain and opioid management among
patients with chronic kidney disease (CKD). Design. Systematic review. Methods. A …

What is known and Objective: Concern has been expressed regarding the potential over‐
prescription of benzodiazepines (BZDs) and their potential for misuse and abuse. Patterns of …

BACKGROUND AND OBJECTIVES: National guidelines have recommended against
codeine use in children, but little is known about prescribing patterns in the United States …

OBJECTIVES: To determine the prevalence and factors associated with use of potentially
inappropriate medications (PIMs) in older adults undergoing surgery. DESIGN …