The study of tumor biology has, in recent years, focused on the abnormal regulation of
growth control an neoplastic cells and on the genes that control tumor cell proliferation …

The production of metastasis appears to involve a number of different proteases including
the urokinase form of plasminogen activator, cathepsin B, cathepsin D and various …

The extracellular protease urokinase is known to be crucially involved in morphogenesis,
tissue repair and tumor invasion by mediating matrix degradation and cell migration …

Proteases are crucial for cancer metastasis, but due to lack of assays, their role in
intravasation has not yet been tested. We have developed a human Alu sequence PCR …

Sonodynamic therapy (SDT) has been proposed as a new modality for cancer management
through low-intensity ultrasound induced activation of sonosensitizers. Here, we designed a …

The surface receptor for urokinase plasminogen activator (uPAR) has been recognized in
recent years as a key molecule in regulating plasminogen mediated extracellular …

The GPI‐anchored urokinase plasminogen activator receptor (uPAR) does not internalize
free urokinase (uPA) but readily internalizes and degrades uPA: serpin complexes in a …

Action of purified human cathepsin B on recombinant single-chain urokinase-type
plasminogen activator (pro-uPA) generated enzymatically active two-chain uPA (HMW-uPA) …

Urokinase and its receptor are essential components of the cell migration machinery,
providing an inducible, transient and localized cell surface proteolytic activity. This activity …

The receptor for urokinase plasminogen activator (uPA) has been previously shown not to
internalize its ligand, but rather to focalize its activity at the cell surface, allowing a regulated …