The introduction of atypical antipsychotics (AAPs) since the discovery of its prototypical drug
clozapine has been a revolutionary pharmacological step for treating psychotic patients as …

New data on the pharmacology of tricyclic antidepressants (TCAs), their affinities for human
cloned CNS receptors and their cytochrome P450 enzyme inhibition profiles, allow improved …

Fear is an adaptive component of the acute “stress” response to potentially-dangerous
(external and internal) stimuli which threaten to perturb homeostasis. However, when …

Over the past decade, psychedelic compounds have emerged as potentially transformative
therapeutics for a variety of intractable neuropsychiatric conditions. However, historically …

Agomelatine (S20098) displayed p K i values of 6.4 and 6.2 at native (porcine) and cloned,
human (h) 5-hydroxytryptamine (5-HT) 2C receptors, respectively. It also interacted with h5 …

Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …

Most antidepressants change sleep; in particular, they alter the physiological patterns of
sleep stages recorded overnight with EEG and other physiological measures. These effects …

Since their discovery in the mammalian brain, it has been apparent that serotonin (5-HT)
and dopamine (DA) interactions play a key role in normal and abnormal behavior …

Recently, the addition of drugs with prominent 5-HT 2 receptor antagonist properties
(risperidone, olanzapine, mirtazapine, and mianserin) to selective serotonin reuptake …

Abstract Serotonin (5-HT) 2C receptors play an important role in the modulation of
monoaminergic transmission, mood, motor behaviour, appetite and endocrine secretion …