Natural compounds are widely used to prevent and treat various diseases due to their
antioxidant and anti-inflammatory effects. As a kind of promising natural compound, plant …

In 1892, JL Wolff proposed that bone could respond to mechanical and biophysical stimuli
as a dynamic organ. This theory presents a unique opportunity for investigations on bone …

The host immune response effecting on biomaterials is critical to determine implant fates
and bone regeneration property. Bone marrow stem cells (BMSCs) derived exosomes …

Rationale: Osteoporosis is a severe bone disorder that is a threat to our aging population.
Excessive osteoclast formation and bone resorption lead to changes in trabecular bone …

Bone is an extremely dynamic tissue, undergoing continuous remodeling for its whole
lifetime, but its regeneration or augmentation due to bone loss or defects are not always …

Physical activity or appropriate exercise prevents the development of osteoporosis.
However, the exact mechanism remains unclear although it is well accepted that exercise or …

Mesenchymal stem cells (MSCs) secrete paracrine trophic factors that are beneficial for
tissue regeneration. In this study, a sponge-like scaffold with hierarchical and interconnected …

Background Patients with diabetes have an increased risk of nonunion and delayed union of
fractures. Macrophages have been shown as a key player in diabetic complications …

MicroRNAs (miRNAs) broadly regulate normal biological functions of bone and the
progression of fracture healing and osteoporosis. Recently, it has been reported that miR …

Osteoarthritis (OA) is the most common degenerative joint disease that causes painful
swelling and permanent damage to the joints in the body. The molecular mechanisms of OA …