Cell migration is fundamental to establishing and maintaining the proper organization of
multicellular organisms. Morphogenesis can be viewed as a consequence, in part, of cell …

Introduction 3. Reactive oxygen species in tumor growth and cellular survival 4. Reactive
oxygen species in cell motility and metastasis formation 5. Generation of reactive oxygen …

Imatinib, a potent inhibitor of the oncogenic tyrosine kinase BCR–ABL, has shown
remarkable clinical activity in patients with chronic myelogenous leukaemia (CML) …

ABL-family proteins comprise one of the best conserved branches of the tyrosine kinases.
Each ABL protein contains an SH3-SH2-TK (Src homology 3–Src homology 2–tyrosine …

Enveloped viruses gain entry into host cells by fusing with cellular membranes, a step that is
required for virus replication. Coronaviruses, including the severe acute respiratory …

Cancer cells produce high amounts of reactive oxygen species (ROS) and evade apoptosis.
Hydroperoxides support proliferation, invasion, migration and angiogenesis, but at higher …

Emerging evidence indicates that once established, synapses and dendrites can be
maintained for long periods, if not for the organism's entire lifetime. In contrast to the wealth …

Background & Aims: The pathogenesis of Helicobacter pylori (Hp)-associated diseases
depends on a specialized type IV secretion system. This type IV secretion system injects the …

Helicobacter pylori induces a strong motogenic response in infected gastric epithelial host
cells, which is enhanced by translocation of the pathogenic factor cytotoxin-associated gene …

β1 integrin has been shown to promote metastasis in a number of tumor models, including
breast, ovarian, pancreatic, and skin cancer; however, the mechanism by which it does so is …