Background Synapse damage and loss are fundamental to the pathophysiology of
Alzheimer's disease (AD) and lead to reduced cognitive function. The goal of this review is to …

Amyloid-β (Aβ) pathology is one of the earliest detectable brain changes in Alzheimer's
disease (AD) pathogenesis. The overall load and spatial distribution of brain Aβ can be …

Multifactorial mechanisms underlying late-onset Alzheimer's disease (LOAD) are poorly
characterized from an integrative perspective. Here spatiotemporal alterations in brain …

Tau pathology is the main driver of neuronal dysfunction in 4-repeat tauopathies, including
cortico-basal degeneration and progressive supranuclear palsy. Tau is assumed to spread …

Although amyloid imaging with PiB-PET ([C-11] Pittsburgh Compound-B positron emission
tomography), and now with F-18-labeled tracers, has produced remarkably consistent …

Importance Mounting evidence suggests that sex differences exist in the pathologic
trajectory of Alzheimer disease. Previous literature shows elevated levels of cerebrospinal …

Alzheimer's disease (AD) is a slowly progressing disorder in which pathophysiological
abnormalities, detectable in vivo by biomarkers, precede overt clinical symptoms by many …

Computer Aided Diagnosis (CAD) constitutes an important tool for the early diagnosis of
Alzheimer's Disease (AD), which, in turn, allows the application of treatments that can be …

Importance An increased tau positron emission tomography (PET) signal in the medial
temporal lobe (MTL) has been observed in older individuals in the absence of amyloid-β …

In 2010, we put forward a hypothetical model of the major biomarkers of Alzheimer's disease
(AD). The model was received with interest because we described the temporal evolution of …