R-spondin (RSPO) proteins constitute a family of four secreted glycoproteins (RSPO1–4)
that have appeared as multipotent signaling ligands. The best-known molecular function of …

IQGAP scaffold proteins are evolutionarily conserved in eukaryotes and facilitate the
formation of complexes that regulate cytoskeletal dynamics, intracellular signaling, and …

Therapies targeting immune checkpoints have shown great clinical potential in a subset of
patients with cancer but may be hampered by a failure to reverse the immunosuppressive …

Rationale: Macrophages are critically involved in wound healing following myocardial
infarction (MI). Lgr4, a member of LGR (leucine-rich repeat-containing G protein-coupled …

Acquired drug resistance is a major challenge for cancer therapy and is the leading cause of
cancer mortality; however, the mechanisms of drug resistance are diverse and the strategy …

Tumor suppressors ZNRF3 and RNF43 inhibit Wnt signaling through promoting degradation
of Wnt coreceptors Frizzled (FZD) and LRP6, and this activity is counteracted by stem cell …

Since its discovery in 1994, recognized cellular functions for the scaffold protein IQGAP1
have expanded immensely. Over 100 unique IQGAP1-interacting proteins have been …

The scaffold protein IQGAP1 assembles multiprotein signaling complexes to influence
biological functions. Cell surface receptors, particularly receptor tyrosine kinases and G …

Deregulation of the β-catenin signaling has long been associated with cancer. Intracellular
components of this pathway, including axin, APC, and β-catenin, are frequently mutated in a …

Simple Summary IQ motif-containing GTPase-activating protein 1 (IQGAP1) is a signal
scaffolding protein that regulates a range of cellular activities by facilitating signal …