血管内皮细胞和内皮细胞释放的活性因子是调控血管舒张功能的重要因素. 糖尿病是慢性心血管
疾病的高危因素之一. 目前认为高糖和糖尿病引起的内皮细胞功能障碍是造成血管功能改变 …

Vascular complications of diabetes pose a severe threat to human health. Prevention and
treatment protocols based on a single vascular complication are no longer suitable for the …

Periodontitis is a chronic inflammatory disease caused by the presence of a bacterial biofilm
known as dental plaque. This biofilm affects the supporting apparatus of the teeth, especially …

Rationale: Cerebrovascular function is critical for brain health, and endogenous vascular
protective pathways may provide therapeutic targets for neurological disorders. S1P …

Diabetes mellitus (DM) is a disorder due to the inability properly to metabolize glucose
associated with dysregulation of metabolic pathways of lipids and proteins resulting in …

Changes in the cerebral microenvironment caused by acute ischemic stroke-reperfusion are
the main obstacle to the recovery of neurological function and an important cause of stroke …

Vascular dementia (VaD) is cognitive decline linked to reduced cerebral blood perfusion, yet
there are few therapeutic options to protect cognitive function following cerebrovascular …

Ischemic stroke is a leading cause of morbidity and mortality among type 2 diabetic patients.
Preclinical and translational studies have identified critical pathophysiological mediators of …

Diabetic neuropathy (DN) encompasses a group of clinical or subclinical manifestations
involving a dysfunction in the peripheral nervous system. The cause of the dysfunction is the …

Intravenous administration of tissue-type plasminogen activator (IV tPA) therapy has long
been considered a mainstay in ischemic stroke management. However, patients respond to …