Prodrugs of triterpenoids and their derivatives

M Zhou, RH Zhang, M Wang, GB Xu, SG Liao - European Journal of …, 2017 - Elsevier
Triterpenoids are structurally diverse organic compounds that exist widely as natural
products. Triterpenoids and their derivatives possess a wide range of biological effects …

Antiviral activities of oleanolic acid and its analogues

V Khwaza, OO Oyedeji, BA Aderibigbe - Molecules, 2018 - mdpi.com
Viral diseases, such as human immune deficiency virus (HIV), influenza, hepatitis, and
herpes, are the leading causes of human death in the world. The shortage of effective …

Recent advances in medicinal chemistry of oleanolic acid derivatives

YH Yang, SY Dai, FH Deng, LH Peng, C Li, YH Pei - Phytochemistry, 2022 - Elsevier
Oleanolic acid (OA), a ubiquitous pentacyclic oleanane-type triterpene isolated from edible
and medicinal plants, exhibits a wide spectrum of pharmacological activities and …

[HTML][HTML] Prophylactic and therapeutic roles of oleanolic acid and its derivatives in several diseases

A Sen - World Journal of Clinical Cases, 2020 - ncbi.nlm.nih.gov
Oleanolic acid (OA) and its derivatives are widely found in diverse plants and are naturally
effective pentacyclic triterpenoid compounds with broad prophylactic and therapeutic roles …

Oleanolic Acid Attenuates Insulin Resistance via NF‐κB to Regulate the IRS1‐GLUT4 Pathway in HepG2 Cells

M Li, Z Han, W Bei, X Rong, J Guo… - … and Alternative Medicine, 2015 - Wiley Online Library
The aim of our study is to elucidate the mechanisms of oleanolic acid (OA) on insulin
resistance (IR) in HepG2 cells. HepG2 cells were induced with FFA as the insulin resistance …

Attenuation of renal ischemia/reperfusion injury by oleanolic acid preconditioning via its antioxidant, anti‑inflammatory, and anti‑apoptotic activities

C Long, J Yang, H Yang, X Li… - Molecular Medicine …, 2016 - spandidos-publications.com
Abstract Ischemia/reperfusion (I/R)‑associated acute kidney injury is a major clinical problem
in both native and transplanted kidneys. Renal I/R, and subsequent renal injury, may be …

Advances on the anti-inflammatory activity of oleanolic acid and derivatives

X Zhang, H Wang, Y Xu, M Luan… - Mini Reviews in …, 2021 - ingentaconnect.com
Oleanolic acid can inhibit edema and exhibit obvious inhibitory activity to inflammatory by
activating of the pituitary-adrenal cortical system, inhibiting the synthesis or release of PGs …

Pharmacokinetics in Vitro and in Vivo of Two Novel Prodrugs of Oleanolic Acid in Rats and Its Hepatoprotective Effects against Liver Injury Induced by CCl4

Z Yu, W Sun, W Peng, R Yu, G Li… - Molecular …, 2016 - ACS Publications
Oleanolic acid (OA) is a well-known pentacyclic triterpenoid compound, which has been
used as a dietary supplement and is supplied as an over-the-counter drug for the treatment …

Neonatal intake of oleanolic acid attenuates the subsequent development of high fructose diet-induced non-alcoholic fatty liver disease in rats

TT Nyakudya, E Mukwevho, P Nkomozepi… - … origins of health and …, 2018 - cambridge.org
Dietary manipulations during the early postnatal period are associated with the development
of metabolic disorders including non-alcoholic fatty liver disease (NAFLD) or long-term …

Semisynthesis of Derivatives of Oleanolic Acid from Syzygium aromaticum and Their Antinociceptive and Anti‐Inflammatory Properties

S Rali, OO Oyedeji, OO Aremu… - Mediators of …, 2016 - Wiley Online Library
Oleanolic acid is a pentacyclic triterpenoid compound widely found in plants and well known
for its medicinal properties. Oleanolic acid (OA) was isolated from the ethyl acetate extract of …