Since the discovery of the first trypsinogen mutation in families with hereditary pancreatitis,
pancreatic genetics has made rapid progress. The identification of mutations in genes …

A combination of genetic, environmental, and metabolic factors contribute to the
development and recurrence of acute and chronic pancreatitis; information on all of these is …

Chronic pancreatitis is a persistent inflammatory disease of the pancreas, in which the
digestive protease trypsin has a fundamental pathogenetic role. Here we have analyzed the …

Genetic investigations have provided unique insight into the mechanism of chronic
pancreatitis in humans and firmly established that uncontrolled trypsin activity is a central …

Pancreatic diseases have a strong genetic component. Rather than a classic Mendelian
disorder, recurrent acute and chronic pancreatitis represents truly complex diseases with the …

Acute pancreatitis and chronic pancreatitis are complex inflammatory disorders of the
pancreas with unpredictable severity, complications, and clinical courses. Growing evidence …

Pancreatitis is regarded by clinicians as one of the most complicated and clinically
challenging of all disorders affecting the abdomen. It is classified on the basis of clinical …

Extensive genetic studies of chronic pancreatitis over the past decade have highlighted the
importance of a tightly regulated balance between activation and inactivation of trypsin …

We investigated the biochemical properties and cellular expression of the c. 346C> T (p.
R116C) human cationic trypsinogen (PRSS1) mutant, which we identified in a German …

Purpose Acute pancreatitis is one of the common causes of asparaginase intolerance. The
mechanism is unknown, and genetic predisposition to asparaginase-induced pancreatitis …