Polyglutamine disorders: Pathogenesis and potential drug interventions

S Tandon, P Aggarwal, S Sarkar - Life Sciences, 2024 - Elsevier
Polyglutamine/poly (Q) diseases are a group nine hereditary neurodegenerative disorders
caused due to abnormally expanded stretches of CAG trinucleotide in functionally distinct …

Myc functions downstream of InR and their concurrent upregulation additively restricts pathogenesis of human poly (Q) disorders in Drosophila disease models

S Tandon, S Sarkar - The International Journal of Biochemistry & Cell …, 2024 - Elsevier
Abstract Human polyglutamine [poly (Q)] disorders are caused by abnormal expansion of
CAG repeats in one gene (disease specific), yet a plethora of cellular pathways are found to …