Recent developments and highlights in biomarkers in allergic diseases and asthma

I Eguiluz‐Gracia, TR Tay, M Hew, MM Escribese… - Allergy, 2018 - Wiley Online Library
The potential of precision medicine in allergy and asthma has only started to be explored. A
significant clarification in the pathophysiology of rhinitis, chronic rhinosinusitis, asthma, food …

New developments in imaging idiopathic pulmonary fibrosis with hyperpolarized xenon magnetic resonance imaging

JG Mammarappallil, L Rankine, JM Wild… - Journal of thoracic …, 2019 - journals.lww.com
Idiopathic pulmonary fibrosis (IPF) is a progressive pulmonary disease that is ultimately fatal.
Although the diagnosis of IPF has been revolutionized by high-resolution computed …

[HTML][HTML] CT mucus score and 129Xe MRI ventilation defects after 2.5 years' anti-IL-5Rα in eosinophilic asthma

MJ McIntosh, HK Kooner, RL Eddy, A Wilson… - Chest, 2023 - Elsevier
Background We previously showed in patients with poorly controlled eosinophilic asthma
that a single dose of benralizumab resulted in significantly improved Asthma Control …

Postacute COVID-19 Syndrome: 129Xe MRI Ventilation Defects and Respiratory Outcomes 1 Year Later

HK Kooner, MJ McIntosh, AM Matheson, M Abdelrazek… - Radiology, 2023 - pubs.rsna.org
Background In individuals with postacute COVID-19 syndrome (PACS) and normal
pulmonary function, xenon 129 (129Xe) MRI ventilation defects, abnormal quality-of-life …

Seven pillars of small airways disease in asthma and COPD: supporting opportunities for novel therapies

OS Usmani, MLK Han, DA Kaminsky, J Hogg… - Chest, 2021 - Elsevier
Identification of pathologic changes in early and mild obstructive lung disease has shown
the importance of the small airways and their contribution to symptoms. Indeed, significant …

Quantification of pulmonary functional MRI: state-of-the-art and emerging image processing methods and measurements

M Sharma, PV Wyszkiewicz… - Physics in Medicine …, 2022 - iopscience.iop.org
Pulmonary functional magnetic resonance imaging (PfMRI) provides a way to non-invasively
map and measure the spatial distribution of pulmonary ventilation, perfusion and gas …

Pulmonary functional MRI: Detecting the structure–function pathologies that drive asthma symptoms and quality of life

HK Kooner, MJ McIntosh, V Desaigoudar… - …, 2022 - Wiley Online Library
Pulmonary functional MRI (PfMRI) using inhaled hyperpolarized, radiation‐free gases (such
as 3He and 129Xe) provides a way to directly visualize inhaled gas distribution and …

Specific Ventilation in Severe Asthma Evaluated with Noncontrast Tidal Breathing 1H MRI

DPI Capaldi, NB Konyer, M Kjarsgaard… - Radiology …, 2023 - pubs.rsna.org
Purpose To determine if proton (1H) MRI–derived specific ventilation is responsive to
bronchodilator (BD) therapy and associated with clinical biomarkers of type 2 airway …

Improving Xenon‐129 lung ventilation image SNR with deep‐learning based image reconstruction

NJ Stewart, J de Arcos, AM Biancardi… - Magnetic …, 2024 - Wiley Online Library
Purpose To evaluate the feasibility and utility of a deep learning (DL)‐based reconstruction
for improving the SNR of hyperpolarized 129Xe lung ventilation MRI. Methods 129Xe lung …

Effects of anti-T2 biologic treatment on lung ventilation evaluated by MRI in adults with prednisone-dependent asthma

S Svenningsen, RL Eddy, M Kjarsgaard, G Parraga… - Chest, 2020 - Elsevier
Background The functional consequence of airway obstruction in asthma can be regionally
measured using inhaled gas MRI. Ventilation defects visualized by MRI persist post …