The smallest viable unit of life is the cell. From bacteria to mammals, all cells use the same
nucleic acid-based universal code for the maintenance and inheritance of genetic …

Precursor mRNA splicing is one of the most highly regulated processes in metazoan
species. In addition to generating vast repertoires of RNAs and proteins, splicing has a …

Nuclear proteins are often given a concise title that captures their function, such as
'transcription factor,''polymerase'or 'nuclear-receptor.'However, for members of the …

The C-terminal domain (CTD) of the RNA polymerase II largest subunit consists of multiple
heptad repeats (consensus Tyr1–Ser2–Pro3–Thr4–Ser5–Pro6–Ser7), varying in number …

R-loops are stable nucleic acid structures that have important physiological functions, but
which also pose a significant threat to genomic stability. Increased R-loops cause replication …

ABSTRACT Messenger RNA (mRNA) 3′ end formation is a nuclear process through which
all eukaryotic primary transcripts are endonucleolytically cleaved and most of them acquire a …

Gene transcription in the cell nucleus is a complex and highly regulated process.
Transcription in eukaryotes requires three distinct RNA polymerases, each of which employs …

Circular RNAs (circRNAs) represent an abundant and conserved entity of non-coding RNAs;
however, the principles of biogenesis are currently not fully understood. Here, we identify …

The rate of RNA polymerase II (Pol II) elongation can influence splice site selection in
nascent transcripts, yet the extent and physiological relevance of this kinetic coupling …

The nucleus is highly organized, such that factors involved in the transcription and
processing of distinct classes of RNA are confined within specific nuclear bodies,. One …