There is a number of systemic diseases affecting the cornea. These include endocrine
disorders (diabetes, Graves' disease, Addison's disease, hyperparathyroidism), infections …

Aniridia, a rare congenital disease, is often characterized by a progressive, pronounced
limbal insufficiency and ocular surface pathology termed aniridia-associated keratopathy …

Congenital aniridia is a panocular disorder that is typically characterized by iris hypoplasia
and aniridia-associated keratopathy (AAK). AAK results in the progressive loss of corneal …

Purpose Abnormalities in the limbal niche microenvironment have been suggested to be
causally involved in aniridia-associated keratopathy (AAK), but histological analyses on the …

Many epithelial compartments undergo constitutive renewal in homeostasis but activate
unique regenerative responses following injury. The clear corneal epithelium is crucial for …

Purpose To evaluate conjunctival cell microRNA (miRNAs) and mRNA expression in
relation to observed phenotype of progressive limbal stem cell deficiency in a cohort of …

Purpose To propose an optimized microsurgical and medical approach to reduce the risk of
complications after penetrating keratoplasty (PKP) in patients with aniridia-associated …

Purpose To investigate corneal phenotype in aniridia-associated keratopathy (AAK)
including its earliest manifestations, in relation to PAX6 mutational status. Methods 46 …

Congenital PAX6-aniridia is a rare panocular disease resulting from limbal stem cell
deficiency. In PAX6-aniridia, the downregulation of the retinol-metabolizing enzymes ADH7 …

PAX6 haploinsufficiency related aniridia is characterized by disorder of limbal epithelial cells
(LECs) and aniridia related keratopathy. In the limbal epithelial cells of aniridia patients …